PMID: 9637103Jan 1, 1997Paper

Identification of the HSV-1 genome by "Dot Blot hybridization" in the geniculate ganglion of rabbits

Revue de laryngologie - otologie - rhinologie
J L LlorenteJ A Fernandez

Abstract

Herpes simplex Virus type 1 (HSV-1) was inoculated into 48 rabbits by 3 different routes: 10 rabbits were dosed by mouth, 18 rabbits injected in the tongue and 14 injected in the perineurium of the facial nerve at its entrance into the stylomastoid foramen. Some of the animals were killed after a week and others after three weeks. Facial palsy was produced in none of the cases. Seroconversion was demonstrated in the peripheral blood of 100% of the inoculated animals. Cultures of macerate of the facial nerve and geniculate ganglion, as well as of the ipsilateral medulla, were negative. DNA from HSV-1 was found by "Dot Blot hybridization" technique in 30% of the macerates of the geniculate ganglion and facial nerve and in 60% of the medulla macerate in those animals killed after one week and in 0% of both samples in those killed in the third week. The fact that the HSV-1 could be isolated in the geniculate ganglion of the facial nerve continues to support the possibility of this virus as the causal agent for facial palsy, either as a single disease or associated with other symptoms.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Morphologie : Bulletin De L'Association Des Anatomistes
S MoreauP Delmas
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Si-yuan HanTao Song
© 2022 Meta ULC. All rights reserved