Identification of the key genes and pathways involved in the tumorigenesis and prognosis of kidney renal clear cell carcinoma.

Scientific Reports
Hao CuiYong Da Liu

Abstract

Kidney renal clear cell carcinoma (KIRC) is the most common renal cell carcinoma (RCC). However, patients with KIRC usually have poor prognosis due to limited biomarkers for early detection and prognosis prediction. In this study, we analysed key genes and pathways involved in KIRC from an array dataset including 26 tumour and 26 adjacent normal tissue samples. Weighted gene co-expression network analysis (WGCNA) was performed with the WGCNA package, and 20 modules were characterized as having the highest correlation with KIRC. The upregulated genes in the tumour samples are involved in the innate immune response, whereas the downregulated genes contribute to the cellular catabolism of glucose, amino acids and fatty acids. Furthermore, the key genes were evaluated through a protein-protein interaction (PPI) network combined with a co-expression network. The comparatively lower expression of AGXT, PTGER3 and SLC12A3 in tumours correlates with worse prognosis in KIRC patients, while higher expression of ALOX5 predicts reduced survival. Our integrated analysis illustrated the hub genes involved in KIRC tumorigenesis, shedding light on the development of prognostic markers. Further understanding of the function of the identified KI...Continue Reading

References

May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Oct 10, 2006·Biochimica Et Biophysica Acta·Yves PoirierJ Kalervo Hiltunen
Mar 9, 2007·Biometrical Journal. Biometrische Zeitschrift·Anat Reiner-Benaim
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kwang-Il GohAlbert-László Barabási
Nov 21, 2007·Bioinformatics·Peter LangfelderSteve Horvath
Aug 16, 2008·PLoS Computational Biology·Steve Horvath, Jun Dong
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Nov 25, 2011·Cancer Biomarkers : Section a of Disease Markers·Paul Cairns
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Mar 20, 2013·Molecular Aspects of Medicine·Sara El-GebaliPascale Anderle
Jul 31, 2013·Immunity·Greg T Motz, George Coukos
Oct 12, 2013·International Journal of Cancer. Journal International Du Cancer·Matteo SantoniStefano Cascinu
Jul 6, 2014·Radiology and Oncology·Zhitong BingLei Yang
Sep 10, 2014·Current Protocols in Bioinformatics·Gang SuGary D Bader
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
May 23, 2015·Human Vaccines & Immunotherapeutics·Katherine A MurphyThomas S Griffith
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Jan 17, 2017·Urologic Oncology·Peter J SiskaScott M Haake
Sep 21, 2017·Cancer Research·Kelly D Moynihan, Darrell J Irvine
Sep 30, 2017·CA: a Cancer Journal for Clinicians·Pedro C Barata, Brian I Rini
Mar 7, 2018·Nature Reviews. Clinical Oncology·Filip JankuFunda Meric-Bernstam
Mar 22, 2018·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 214 Investigators
Apr 4, 2018·World Journal of Urology·Sabrina H RossiGrant D Stewart
May 29, 2018·Cancer Metastasis Reviews·Andreas WeigertBernhard Brüne
Jul 1, 2018·Biochimica Et Biophysica Acta. Reviews on Cancer·Danielle J Sanchez, M Celeste Simon
Aug 31, 2018·Frontiers in Genetics·Lushun YuanXinghuan Wang

❮ Previous
Next ❯

Citations

May 20, 2020·Expert Review of Proteomics·Francesca Raimondo, Marina Pitto
Aug 19, 2020·Journal of Receptor and Signal Transduction Research·Yanhui ZhangTao Cui
Apr 14, 2021·World Journal of Surgical Oncology·Yonghui GuiPeng Yang
May 29, 2021·Frontiers in Oncology·Natalya ApanovichAlexander Karpukhin

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE66272

Software Mentioned

DAVID
WGCNA
Network Analyzer
WGCNA R
GraphPad Prism
GraphPad
Cytoscape
Search Tool for the Retrieval of
limma R package
R

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.