Identification of the major chemokines that regulate cell influxes in peritoneal dialysis patients.

Journal of the American Society of Nephrology : JASN
J TekstraR H Beelen

Abstract

To investigate which members of the recently discovered family of chemotactic cytokines (chemokines) are important in leukocyte recruitment to a bacterial inflammation site, four different chemokines in the effluent of peritoneal dialysis patients suffering from acute bacterial peritonitis were measured. The presence of two neutrophil-attracting chemokines, interleukin-8 and human melanoma growth-stimulating activity (huGRO alpha), and two monocyte-attracting members of the chemokine superfamily, monocyte chemotactic protein-1 (MCP-1) and regulated on activation normal T cell expressed and secreted (RANTES), was investigated in patient effluents just before, during, and after a peritonitis episode. This was studied in seven peritonitis effluents of five patients by using chemokine-specific enzyme-linked immunosorbent assays. Cell populations in the dialysates were differentiated on cytocentrifuge preparations. The contribution of the detected chemokines to neutrophilic and monocytic cell influxes in the inflamed peritoneal cavity was analyzed by correlating concentrations of chemokines to the relevant cell numbers present in the dialysates of these patients. The detection of the neutrophil-attracting chemokine interleukin-8 dur...Continue Reading

Citations

Jul 2, 1998·Clinical and Experimental Immunology·C E VisserR H Beelen
Dec 16, 1998·Kidney International·N LameireR H Beelen
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Liesbeth H P HekkingRobert H J Beelen
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Fan Fan HouWilliam F Owen
Nov 3, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Caatje Y le PooleFrans J van Ittersum
Sep 17, 2002·Kidney International. Supplement·Raymond Krediet, Salim Mujais
Nov 26, 2010·Clinical and Vaccine Immunology : CVI·Monika MerkleMarkus Wörnle
Jul 9, 2008·The International Journal of Artificial Organs·K PawlaczykA Breborowicz
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angelique G A WeltenLiesbeth H P Hekking
Sep 17, 2004·The Journal of Urology·Assaad El-HakimBenjamin R Lee
Feb 5, 2005·American Journal of Physiology. Renal Physiology·Michael F Flessner
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Stamatina AgalouPaul J Thornalley
Jul 11, 2008·Kidney International·Hsin-Hui WangChing-Yuang Lin
Nov 14, 2008·Molecular and Cellular Biochemistry·Markus WörnleThomas Sitter

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