PMID: 6967510Jul 1, 1980Paper

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte

The Journal of Experimental Medicine
D T Fearon

Abstract

A human erythrocyte membrane glycoprotein of 205,000 mol wt (gp205) has been identified as the C3b receptor of the erythrocyte, polymorphonuclear leukocyte (PMN), B lymphocyte, and monocyte. Initially, gp205 was sought and characterized as a constituent of the human erythrocyte membrane that can impair activation of the alternative complement pathway by inducing loss of function of the properdin-stabilized amplification C3 convertase (C3b,Bb,P) through displacement of Bb from C3b and by promoting cleavage-inactivation of C3b by C3b inactivator. These inhibitory activities of gp205 suggested that this membrane glyeoprotein had an affinity for C3b and prompted an analysis of its possible identity as the C3b receptor of human peripheral blood cells. The F(ab')2 fragment of rabbit IgG anti-gp205 inhibited the formation of rosettes with sheep EC3b of human erythroeytes, B lymphocytes, monocytes and PMN in a dose-response manner; the 50 percent inhibitory doses were 0.13/mug/ml, 0.90 mug/ml, 1.25 mug/ml, and 1.20 mug/ml of F(ab')2, respectively. Anti-gp205 did not impair the formation of rosettes by monocytes and B lymphocytes with sheep EC3bi or with EC3d. Scatchard analysis of the number of specific (125)I-F(ab')(2) anti-gp205 bind...Continue Reading

References

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D T Fearon, K F Austen
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D T Fearon
Jan 1, 1977·Annual Review of Biochemistry·S C SilversteinZ A Cohn
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J M WeilerD T Fearon
Oct 1, 1975·The Journal of Experimental Medicine·M C GelfandI Green
Oct 1, 1975·The Journal of Experimental Medicine·D T Fearon, K F Austen
Dec 1, 1975·The Journal of Experimental Medicine·J C Unkeless, H N Eisen
Nov 1, 1968·The Journal of Experimental Medicine·W H Lay, V Nussenzweig
Dec 1, 1969·The Journal of Experimental Medicine·H S ShinW B Wood
Mar 1, 1973·The Journal of Experimental Medicine·T P StosselF S Rosen
Jan 1, 1973·The Journal of Immunology : Official Journal of the American Association of Immunologists·L G HunsickerK F Austen
Jul 1, 1968·Experimental Cell Research·I Gigli, R A Nelson

❮ Previous
Next ❯

Citations

Nov 11, 1999·European Journal of Immunology·S SadallahJ A Schifferli
Mar 1, 1997·Arthritis and Rheumatism·S SadallahJ A Schifferli
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·M P Dierich
Oct 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·I V Chebotar'A N Maianskiĭ
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A ZimmermannH Isliker
Jan 1, 1994·Springer Seminars in Immunopathology·B P Morgan, S Meri
Jan 1, 1994·Springer Seminars in Immunopathology·K A DaviesM J Walport
Jan 1, 1994·Springer Seminars in Immunopathology·K R KalliD T Fearon
Jan 1, 1984·Springer Seminars in Immunopathology·M K Pangburn, H J Müller-Eberhard
Jan 1, 1984·Springer Seminars in Immunopathology·R D Schreiber
Feb 1, 1986·European Journal of Clinical Microbiology·D L Coleman
Jan 1, 1988·Springer Seminars in Immunopathology·Y C Ng, J A Schifferli
Aug 1, 1983·Agents and Actions·H P Hartung, U Hadding
Oct 19, 2006·Journal of Molecular Histology·Eberhard BuseFriedhelm Vogel
Feb 10, 1984·Journal of Immunological Methods·A Naess, C O Solberg
Aug 2, 1985·Journal of Immunological Methods·B S ThomsenG Bendixen
Jan 21, 1985·Journal of Immunological Methods·J D OgleJ W Alexander
Nov 23, 1987·Journal of Immunological Methods·Y SugitaM Tomita
Oct 1, 1982·Molecular Immunology·M P DierichT Schulz
Dec 1, 1984·Molecular Immunology·M A Arnaout, H R Colten
Dec 1, 1984·Molecular Immunology·M P Dierich, T F Schulz
Apr 1, 1991·Journal of Reproductive Immunology·B L HsiJ P Atkinson
Oct 1, 1989·Immunology Today·D G Russell, P Talamas-Rohana
Aug 1, 1986·Prostaglandins, Leukotrienes, and Medicine·J CookM Kazatchkine
Apr 29, 1982·Biochimica Et Biophysica Acta·C G Gahmberg, L C Andersson
Feb 1, 1996·Research in Immunology·J P Atkinson
May 14, 2005·Molecular Immunology·Peter Lachmann
Sep 12, 1981·Lancet·I SiegelN Gleicher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.