Identification of the molecular subgroups in coronary artery disease by gene expression profiles

Journal of Cellular Physiology
Xiao-Yan PengQi Li

Abstract

Coronary artery disease (CAD) is the most common type of cardiovascular disease and becomes a leading cause of death worldwide. Aiming to uncover the underlying molecular features for different types of CAD, we classified 352 CAD cases into three subgroups based on gene expression profiles, which were retrieved from the Gene Expression Omnibus database. Also, these subgroups present different expression patterns and clinical characteristics. To uncover the transcriptomic differences between the subgroups, weighted gene co-expression analysis (WGCNA) was used and identified six subgroup-specific WGCNA modules. Characterization of the WCGNA modules revealed that lipid metabolism pathways, specifically upregulated in subgroup I, might be an indicator of increased severity. Moreover, subgroup II was considered as an early-stage of CAD because of normal-like gene expression patterns. In contrast, the mammalian target of rapamycin signaling pathway was significantly upregulated in subgroup III. Although subgroups II and III did not have a significant prognostic difference, their intrinsic biological characteristics were highly different, suggesting that the transcriptome classification may represent risk factors of both age and the i...Continue Reading

References

Dec 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·S Lamon-FavaE J Schaefer
Jan 15, 2002·Journal of the American College of Cardiology·G Michael FelkerChristopher M O'Connor
Feb 13, 2004·Progress in Cardiovascular Diseases·Natalie Bello, Lori Mosca
May 14, 2005·Current Opinion in Lipidology·Søren K Moestrup, Lars Bo Nielsen
Jun 2, 2005·Pharmacotherapy·Michael G MillerAbdul-Karim Elhabyan
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
May 23, 2006·Revista española de cardiología·Jaume MarrugatJaime Aboal
May 15, 2007·Bioinformatics·Sean Davis, Paul S Meltzer
Jul 11, 2008·DNA and Cell Biology·Priyanka SharmaShantanu Sengupta
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Apr 30, 2010·Bioinformatics·Matthew D Wilkerson, D Neil Hayes
May 7, 2011·Bioinformatics·Arthur LiberzonJill P Mesirov
Sep 14, 2012·BMC Genomics·Chrysanthi AinaliSophia Tsoka
Nov 30, 2012·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Sep 28, 2013·Nature Genetics·UNKNOWN Cancer Genome Atlas Research NetworkJoshua M Stuart
Jan 30, 2014·BMJ : British Medical Journal·Huseyin Naci, John P A Ioannidis
Mar 19, 2014·Lancet·Katherine J DickNilesh J Samani
Mar 26, 2014·Nature Reviews. Cardiology·Nathan D Wong
Jul 22, 2014·Nature·Bing ZhangUNKNOWN NCI CPTAC
Sep 3, 2016·Current Cardiology Reports·Milos PjanicThomas Quertermous
Apr 12, 2017·European Journal of Internal Medicine·Domenico GirelliOliviero Olivieri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.