PMID: 9447923Feb 3, 1998Paper

Identification of the nonlinearity governing even-order distortion products in cochlear potentials

Hearing Research
M G van EmstG F Smoorenburg

Abstract

In order to characterize the cochlear transducer nonlinearities which are involved in the generation of the summating potential (SP), we investigated the effect of a change in the electrical operating point of the cochlear transducer on the SP. The electrical operating point of the cochlear transducer was affected by suppressing reversibly the endocochlear potential (EP). This was realized by intravenous injection of furosemide in guinea pig. A differential recording technique was used in the basal turn of the cochlea to measure locally generated even-order distortion products: the SP and the second harmonic component (2F0) of the cochlear microphonics (CM). These potentials were evoked by 2 and 8 kHz stimuli presented at 60 dB SPL. Following furosemide injection, the SP changed polarity twice over time. The zero crossings of the SP coincided with a minimum in the amplitude of 2F0. Concomitantly, the phase of 2F0 shifted about 120 degrees. The changes in the electrical even-order products were comparable to the changes that occurred in a mechanical even-order intermodulation distortion product (the difference tone F2-F1 otoacoustic emission) after furosemide application (Mills et al., J. Acoust. Soc. Am. 94 (1993) 2108-2122). T...Continue Reading

References

Jan 1, 1977·Acta Oto-laryngologica·J M Aran, R C de Sauvage
Aug 22, 1992·Proceedings. Biological Sciences·C J KrosG P Richardson
May 1, 1991·The Journal of the Acoustical Society of America·R ProbstG K Martin
Apr 1, 1990·The Journal of the Acoustical Society of America·P Dallos, M A Cheatham
Sep 15, 1988·Hearing Research·J Santos-Sacchi, J P Dilger
Jan 1, 1985·Hearing Research·J Syka, I Melichar
Oct 1, 1993·The Journal of the Acoustical Society of America·D M MillsE W Rubel
Aug 5, 1993·Nature·F JaramilloA J Hudspeth
Aug 1, 1995·Hearing Research·M G van EmstG F Smoorenburg
Dec 1, 1996·Hearing Research·M G van EmstG F Smoorenburg

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Citations

Nov 6, 2003·Hearing Research·Steven SluyterGuido F Smoorenburg
Jul 27, 2002·The Journal of the Acoustical Society of America·Lin BianEmily Miller
Dec 18, 2004·The Journal of the Acoustical Society of America·Chul-Hee ChoiDavid Lerner
Jan 22, 2005·The Journal of the Acoustical Society of America·Lin Bian
Apr 28, 2005·Hearing Research·Natalie L M CappaertGuido F Smoorenburg
Mar 16, 2000·Neuroreport·S F KlisG F Smoorenburg
Jul 26, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Thijs T G JansenWilko Grolman

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