Identification of the nuclear export signal in the helix-loop-helix inhibitor Id1

FEBS Letters
Jun MakitaYoshifumi Yokota

Abstract

Id proteins play important roles in cellular differentiation and proliferation by negatively regulating basic helix-loop-helix transcription factors. Although their intracellular localization may change depending on the biological situation, little is known about the molecular determinants underlying such changes. Here we report the identification of a nuclear export signal (NES) in Id1. The identified NES was different from that of Id2, but had the ability to confine heterologous green fluorescent protein to the cytoplasm. Thus, our results indicate that the intracellular localization of Id1 is regulated differently from that of Id2.

References

May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·M V BaroneL Philipson
Aug 8, 1998·Trends in Cell Biology·J D NortonF Sablitzky
Oct 6, 1998·Annual Review of Biochemistry·I W Mattaj, L Englmeier
Jul 8, 1999·Current Opinion in Cell Biology·S A Adam
Dec 28, 1999·Annual Review of Cell and Developmental Biology·D Görlich, U Kutay
Nov 14, 2001·The Journal of Biological Chemistry·Martin E MatsumuraColeen A McNamara
Feb 13, 2002·Oncogene·Y Yokota
Mar 7, 2002·The Journal of Biological Chemistry·Koji ItahanaJudith Campisi
Jan 10, 2003·Nucleic Acids Research·Tanja la CourSøren Brunak
Jun 7, 2003·Developmental Cell·Mythili Suntharalingam, Susan R Wente
Jul 31, 2003·Trends in Cell Biology·Marianna B Ruzinova, Robert Benezra
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sylvia FongPierre-Yves Desprez
Jan 22, 2004·Biochemical and Biophysical Research Communications·Ifat FajermanAaron Ciechanover
Sep 29, 2004·Journal of Molecular Biology·Matthias BerseWolfgang Dubiel
Nov 26, 2004·The Journal of Biological Chemistry·Hisanori Kurooka, Yoshifumi Yokota

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Citations

Mar 26, 2013·Biochemical and Biophysical Research Communications·Hisanori KurookaYoshifumi Yokota
Jul 20, 2007·The Prostate·Ananthi J AsirvathamJaideep Chaudhary
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nigel L Hammond, Colin A B Jahoda
Apr 7, 2007·The Journal of Biological Chemistry·Koichi NishiyamaHiroki Kurihara
Dec 31, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·A-Ching ChaoDing-I Yang
Jul 25, 2021·Cell and Tissue Research·Yu-Hsuan ChuChristian Schachtrup

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