PMID: 109473Apr 1, 1979

Identification of the paraproteins and clinical significance of more than one paraprotein and clinical significance of more than one paraprotein in serum of 56 patients

Journal of Clinical Pathology
M E GoreJ Kohn

Abstract

Sera from 56 patients with more than one paraprotein were investigated for immunoglobin class and light chain type of each paraprotein. The patients were divided into two groups according to the diagnosis, that is myeloma and macroglobulinaemia or others. The frequency of combinations of paraproteins was considered in the whole series and in the two groups. The laboratory and clinical findings were analysed to investigate the diagnostic and prognostic significance of more than one paraprotein in a serum. It is concluded that a lower percentage of patients with more than one paraprotein can definitely be shown to have myeloma than might be expected from studies on monoclonal paraproteinaemia, that patients having IgA paraproteins in the serum had the poorest prognosis, and that paraproteins with lambda light chains were more likely to be associated with myeloma or macroglobulinaemia. A discriminant analysis of ESR and total paraprotein levels in the two groups of patients showed that combinations of the two parameters were not more effective at distinguishing the groups than the ESR alone.

References

Jan 1, 1978·Journal of Immunological Methods·J Kohn, P Riches
Sep 1, 1976·Analytical Biochemistry·D W West, G E Towers
Jan 1, 1978·Clinical Immunology and Immunopathology·B G van CampJ Radl
Apr 1, 1967·The American Journal of Medicine·N CosteaP Heller
Oct 26, 1967·The New England Journal of Medicine·B J RosenK J Bloch
Jan 1, 1971·Advances in Clinical Chemistry·J R Hobbs

Citations

Feb 2, 1980·British Medical Journal
Dec 1, 1988·International Journal of Oral and Maxillofacial Surgery·E J RaubenheimerJ C Senekal
Sep 1, 1983·Cancer·H GersteinM Susin
Jun 1, 1986·Acta Neurologica Scandinavica·R O BaileyA Y Wu
Mar 15, 2005·Journal of Epidemiology·Takuya SugieHiroshi Une
Sep 1, 1984·The Proceedings of the Nutrition Society·L Davies
Oct 1, 1983·Scandinavian Journal of Haematology·R BartlG Hoffmann-Fezer
Mar 1, 1987·Annals of Clinical Biochemistry·J T WhicherC Warren
Sep 11, 2008·Annals of Clinical Biochemistry·Maarten T M RaijmakersHuib L Vader

Related Concepts

Erythrocyte Sedimentation Rate Result
IgA2
Lambda-x Immunoglobulin
Familial Waldenstrom's Macroglobulinaemia
Multiple Myeloma
Plasma Cell Dyscrasia
Paraproteins
Retrospective Studies

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