PMID: 5257132Jun 1, 1969Paper

Identification of the polypeptide chains involved in the cross-linking of fibrin

Proceedings of the National Academy of Sciences of the United States of America
R Chen, R F Doolittle

Abstract

The stabilization of fibrin clots by activated factor XIII involves two different sets of cross-linked chains. In one case (type I) two gamma-chains are linked to each other, indicating that gamma-chains have both donor (suitable lysyl-) and acceptor (suitable glutaminyl-) functions. A second system (type II) consists of a gamma-chain linked to an alpha-chain. Experiments with a substitute donor (glycine ethylester) indicate that only gamma-chains have enzyme-accessible acceptor sites, suggesting that alpha-chain participation is limited to lysyl side chains. A model molecular arrangement for fibrin has been suggested which accommodates all the data.

References

May 1, 1967·British Journal of Haematology·D Kay, B J Cuddigan
Feb 26, 1968·Biochemical and Biophysical Research Communications·S Matacić, A G Loewy
Apr 19, 1968·Biochemical and Biophysical Research Communications·L LorandS Tokura
May 20, 1966·Science·T SasakiJ R Shainoff
Sep 26, 1966·Archives of Biochemistry and Biophysics·P A McKeeR L Hill
Sep 22, 1966·Biochemical and Biophysical Research Communications·S Matacić, A G Loewy
Dec 1, 1964·Biochemistry·L LORAND, A JACOBSEN
Jun 23, 1962·Nature·L LORANDA JACOBSEN
Jul 1, 1951·Archives of Biochemistry and Biophysics·K LAKI

❮ Previous
Next ❯

Citations

Jan 1, 1974·Journal of Supramolecular Structure·R F Doolittle
Jun 1, 1974·Thrombosis Research·F R MatthiasZ Wegrzynowicz
Mar 1, 1978·Thrombosis Research·G G LindseyL R Purves
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R Chen, R F Doolittle
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M W MosessonJ P DiOrio
Sep 1, 1971·British Journal of Haematology·R P McDonaghF Duckert
Feb 1, 1974·British Journal of Haematology·R D RosenbergL Lorand
Mar 6, 2003·Vox Sanguinis·Stephen J Everse
Dec 8, 1972·Annals of the New York Academy of Sciences·R F DoolittleG L Wooding
Dec 8, 1972·Annals of the New York Academy of Sciences·R P McDonaghB Blombäck
Jun 18, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenneth G Mann
Mar 1, 1976·The Journal of Clinical Investigation·M W MosessonD Ménaché
Jul 21, 1972·Biochimica Et Biophysica Acta·T Takagi, K Konishi
Nov 17, 1970·Biochimica Et Biophysica Acta·R S AsquithK L Gardner
Dec 8, 1972·Annals of the New York Academy of Sciences·L LorandA Gray
Jan 18, 1988·Biochimica Et Biophysica Acta·R R Hantgan
Mar 5, 1973·Biochemical and Biophysical Research Communications·T Takagi, R F Doolittle
Jun 15, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Even MansethRagnar Flengsrud
Mar 1, 1979·Progress in Cardiovascular Diseases·J F Davidson, I D Walker
Feb 4, 1974·Biochemical and Biophysical Research Communications·L L ShenJ Hermans
Jul 2, 1971·Biochemical and Biophysical Research Communications·R F DoolittleF Lau
Jan 6, 1970·Biochemical and Biophysical Research Communications·T Takagi, S Iwanaga
Nov 5, 1999·Biophysical Journal·E A RyanL Lorand
Jan 28, 1992·Biochemistry·K R Siebenlist, M W Mosesson
Jan 15, 1972·Experientia·E A Beck
Dec 8, 1972·Annals of the New York Academy of Sciences·J J PisanoJ S Finlayson
Jan 24, 2012·Anesthesia and Analgesia·Richard B Weiskopf
Jul 27, 2000·The Journal of Biological Chemistry·M MoaddelD H Farrell
May 30, 1997·The Journal of Biological Chemistry·L A Falls, D H Farrell
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·I M Nilsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
P A McKeeR L Hill
Biochemical and Biophysical Research Communications
R F DoolittleF Lau
Proceedings of the National Academy of Sciences of the United States of America
R Chen, R F Doolittle
© 2021 Meta ULC. All rights reserved