Identification of the porosome complex in the hair cell.

Cell Biology International Reports
Dennis G DrescherMarian J Drescher

Abstract

Porosomes are proposed to be the universal secretory machinery of the cell plasma membrane, where membrane-bound secretory vesicles transiently dock and fuse to expel their contents to the extracellular space during cell secretion. In neurons, porosomes are manifested as cup-shaped lipoprotein structures in the presynaptic membrane, 12-17 nm in diameter and possessing a central plug. Hair cells of hearing and balance secrete transmitter from synaptic vesicles in sensory signal transduction, but it has not previously been demonstrated that these mechanosensory cells possess porosome structures that could participate in the secretory process. In the current study, we provide, for the first time, evidence obtained using transmission electron microscopy that porosome structures indeed exist in the hair cell, suggesting a mechanism of hair-cell transmitter secretion markedly different from that of the exocytotic process currently proposed.

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Citations

Apr 14, 2012·Molecular and Cellular Neurosciences·Neeliyath A RamakrishnanDennis G Drescher
Jun 30, 2015·Neuroscience Research·Mzia G ZhvaniaTamar G Lordkipanidze
May 16, 2015·Micron : the International Research and Review Journal for Microscopy·Mzia G ZhvaniaTamar G Lordkipanidze
May 11, 2012·Micron : the International Research and Review Journal for Microscopy·Nadezhda J JaparidzeMzia G Zhvania
Mar 1, 2017·ACS Chemical Neuroscience·Kenneth T LewisBhanu P Jena
Nov 3, 2015·Endocrinology·Akshata R NaikBhanu P Jena
Aug 13, 2015·Experimental Biology and Medicine·Akshata R NaikBhanu P Jena
Aug 4, 2012·Experimental Biology and Medicine·Bhanu P Jena

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