Identification of the Potential Key Long Non-coding RNAs in Aged Mice With Postoperative Cognitive Dysfunction

Frontiers in Aging Neuroscience
Ming LiJin Liu

Abstract

Postoperative cognitive dysfunction (POCD) is a significant complication of surgery, particularly in elderly patients. Emerging researches showed that long non-coding RNA (lncRNA) may play a vital role in the pathogenesis of POCD. Here we aimed to identify potential key lncRNAs involved in the development of POCD. LncRNA and mRNA expression profiles in hippocampal tissues from POCD and control mice were analyzed by microarray assay. Gene ontology (GO) and KEGG pathway enrichment analyses were conducted to probe the functions of dysregulated genes. Then, important factors of the mainly affected biological processes were measured in the hippocampus. Correlated coding-non-coding co-expression (CNC) networks were constructed. Finally, the potential key pairs of lncRNA and target mRNA implicated in POCD were probed. Our data showed that 868 differentially expressed lncRNAs and 690 differentially expressed mRNAs were identified in total. GO and KEGG analyses indicated that the differentially expressed genes were mainly associated with inflammatory and apoptotic signaling pathways. Surgery-induced inflammatory cytokines and apoptosis were significantly increased in hippocampal tissues of aged mice. In CNC network analysis, we found th...Continue Reading

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Citations

Apr 27, 2021·ACS Chemical Neuroscience·Liang HeMeilin Lu

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Datasets Mentioned

BETA
AK016122
GSE113738

Methods Mentioned

BETA
electrophoresis
PCR
feature extraction
GTPase

Software Mentioned

GraphPad
Ensembl
NIH ImageJ
CageCenter
GeneSpring GX
Prism
Cytoscape
Arraystar
Agilent

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