Identification of the regions of Fv1 necessary for murine leukemia virus restriction

Journal of Virology
Kate N BishopJonathan P Stoye

Abstract

The Fv1 gene restricts murine leukemia virus replication via an interaction with the viral capsid protein. To study this interaction, a number of mutations, including a series of N-terminal and C-terminal deletions, internal deletions, and a number of single-amino-acid substitutions, were introduced into the n and b alleles of the Fv1 gene and the effects of these changes on virus restriction were measured. A significant fraction of the Fv1 protein was not required for restriction; however, retention of an intact major homology region as well as of domains toward the N and C termini was essential. Binding specificity appeared to be a combinatorial property of a number of residues within the C-terminal portion of Fv1.

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Citations

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Oct 22, 2004·Nature Immunology·Paul D Bieniasz
Feb 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yuhe YanChristine A Kozak
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Oct 15, 2010·Journal of Virology·Amit KapoorW Ian Lipkin
Mar 29, 2013·Journal of Virology·Sadayuki Ohkura, Jonathan P Stoye
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