PMID: 9188550Jul 1, 1997Paper

Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell

Journal of Virology
E M MiyashitaD A Thorley-Lawson

Abstract

Epstein-Barr (EBV) is a powerful immortalizing virus for human B lymphocytes in vitro and is associated with several human neoplasias in vivo. Previously, we have shown that the majority of EBV-infected cells in the peripheral blood of healthy, persistently infected individuals do not express the activated phenotype, e.g., high levels of cell surface CD23 and CD80 (B7), characteristically expressed on in vitro-immortalized cells. Here, we show that > or = 90% of the CD23-, virus-infected cells in the peripheral blood are in G0 and therefore resting. The remaining cells may be G1 arrested, but we were unable to detect a significant number of cells traversing the S-G2-M stages of the cell cycle. The mRNA for LMP2A, but not EBNA1 originating from Qp, was readily detected in this population, and these cells appear competent in the processing and presentation of antigen by class I major histocompatibility complex. We propose that these resting B cells are the site of long-term latent persistence for EBV. We further propose that the persistence of the virus in a resting B7- B cell provides an important mechanism to escape immunosurveillance. The demonstration that EBV can persist latently in a resting B cell means that the immortaliz...Continue Reading

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Citations

Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·G J Babcock, D A Thorley-Lawson
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J MossR Khanna
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H Crawford
Jun 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D T RoweM Green
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·Barbara AdlerGeorg W Bornkamm
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Donna HochbergDavid A Thorley-Lawson
Nov 17, 2004·Reviews in Medical Virology·Wolfgang Amon, Paul J Farrell
Jan 31, 2006·Expert Review of Anti-infective Therapy·Maher K Gandhi
Mar 8, 2007·Bioinformatics·Filippo CastiglioneDavid Thorley-Lawson
Nov 23, 2010·Blood·David T Vereide, Bill Sugden
May 9, 2012·The International Journal of Cardiovascular Imaging·Michael JeserichAnnette Geibel
Oct 18, 2016·British Journal of Haematology·Austen J J WorthClaire Booth
Feb 18, 1999·Molecular and Cellular Biology·I K RufJ T Sample
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilio FlañoMarcia A Blackman
Mar 27, 2002·International Reviews of Immunology·M MerchantS K Pierce
Mar 27, 2004·The New England Journal of Medicine·David A Thorley-Lawson, Andrew Gross
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Casper PaludanChristian Münz
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew J GrossDavid A Thorley-Lawson
Oct 13, 2006·Journal of Virology·Mark Rovedo, Richard Longnecker

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