Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method

Journal of Proteomics
Nai-Jun FanNian-Long Meng

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common primary malignant tumor of digestive tract. However, the early diagnosis and molecular mechanisms that underlie tumor formation and progression have been progressed less. To identify new biomarkers for ESCC, we performed a comparative proteomic research. Isobaric tags for relative and absolute quantitation-based proteomic method was used to screen biomarkers between ESCC and normal. 802 non-redundant proteins were identified, 39 of which were differentially expressed with 1.5-fold difference (29 up-regulated and 10 down-regulated). Through Swiss-Prot and GO database, the location and function of differential proteins were analyzed, which are related to the biological processes of binding, cell structure, signal transduction, cell adhesion, etc. Among the differentially expressed proteins, TP-alpha, collagen alpha-1(VI) chain and S100A9 were verified to be upregulated in 77.19%, 75.44% and 59.65% of ESCC by immunohistochemistry and western-blot. Diagnostic value of these three proteins was validated. These results provide new insights into ESCC biology and potential diagnostic and therapeutic biomarkers, which suggest that TP-alpha, collagen alpha-1(VI) chain an...Continue Reading

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Citations

Nov 20, 2015·Proteomics. Clinical Applications·Caroline Coghlin, Graeme I Murray
Oct 11, 2016·Expert Review of Proteomics·Kazuto HaradaJaffer A Ajani
Jan 16, 2018·Cancer Biology & Therapy·Bohan ZhangQingchen Wu
Feb 15, 2018·Journal of Dental Research·P P ArgyrisM C Herzberg
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Louise Y FongCarlo M Croce

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