Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non-Small-Cell Lung Cancer in the Chinese Population.

The Journal of Molecular Diagnostics : JMD
Jianfeng XianLei Yang

Abstract

The recent discovery of circular RNAs (circRNAs) in serum exosomes suggests a novel and potentially useful tool for noninvasive cancer diagnosis. However, there are currently no substantial studies addressing this topic. RNA-sequencing analysis was performed between three pairs of non-small-cell lung cancer (NSCLC) patients and controls. The diagnostic values of exosomal circRNAs were assessed in a training set, validation set 1, and validation set 2. A total of 46 abnormally expressed circRNAs were identified. Among these, circ_0047921, circ_0056285, and circ_0007761 were found to display significant diagnostic validity for NSCLC. In distinguishing NSCLC cases from healthy controls, the panel of aforementioned circRNAs exhibited area under the curve (AUC) values of 0.926 (95% CI, 0.895-0.956) in the training set and 0.919 (95% CI, 0.877-0.962) in validation set 1. Circ_0047921 could distinguish NSCLC cases from chronic obstructive pulmonary disease controls (AUC, 0.890; 95%CI, 0.831-0.948), whereas the circ_0056285 and circ_0007761 combination could distinguish NSCLC cases from tuberculosis controls (AUC, 0.820; 95% CI, 0.739-0.902). For an early NSCLC diagnosis, similar results were observed for these circRNAs in distinguishi...Continue Reading

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Citations

Dec 17, 2020·Frontiers in Cell and Developmental Biology·Yanhua XuShaoqing Ju
Feb 26, 2021·International Journal of Nanomedicine·Sangiliyandi GurunathanJin-Hoi Kim
Jun 18, 2021·Frontiers in Molecular Biosciences·Lanxiang HuangFubing Wang
Oct 2, 2021·Frontiers in Cell and Developmental Biology·Feifan WangXiaodong Jin
Nov 4, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ziyi PengZhaohui Gong

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