PMID: 9632608Jun 25, 1998Paper

Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant

Infection and Immunity
P J ValentineF Heffron

Abstract

A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the panel of mutants initially chosen for this study, three mutants with comparable levels of attenuation elicited higher Salmonella-specific serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine strain. The three mutants, CL288, CL401, and CL554, also elicited a better protective immune response than the aroA control strain, after a single oral dose of 1 x 10(9) to 2 x 10(9) bacteria.

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Citations

Jun 29, 2011·The Journal of Experimental Medicine·Sau K LeeCarola G Vinuesa
Apr 26, 2000·FEMS Microbiology Letters·J P Bohin
Jun 9, 2000·Molecular Microbiology·M J WorleyF Heffron
Sep 24, 2004·Infection and Immunity·Camille N Kotton, Elizabeth L Hohmann
Jun 3, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingke KongRoy Curtiss
Apr 28, 2001·Journal of Bacteriology·V CogezJ P Bohin
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·T L Norris, A J Bäumler
Aug 23, 2005·Infection and Immunity·Andrea HumphriesAndreas J Bäumler
Dec 22, 2005·Cellular Microbiology·Ernesto J Muñoz-Elías, John D McKinney
Oct 13, 2006·Current Opinion in Infectious Diseases·J A AdachiC D Ericsson
Apr 7, 2011·Bioengineered Bugs·Chwanrow K BabanMark Tangney
Mar 23, 2000·FEMS Immunology and Medical Microbiology·A DarjiS Weiss
Mar 23, 2000·FEMS Immunology and Medical Microbiology·D BumannT F Meyer
Apr 13, 1999·Infectious Disease Clinics of North America·J D Gradon, L I Lutwick

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