PMID: 7542948May 1, 1995Paper

Identification of three human sequences with viral superantigen-specific primers

Mammalian Genome : Official Journal of the International Mammalian Genome Society
S IndraccoloB Salmons

Abstract

The open reading frame (ORF) in the long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) has recently been shown to encode multiple products including a negative acting factor (Naf) and a superantigen (Sag). Expression of superantigens from endogenous MMTV loci in the mouse results in the deletion of whole classes of T cells. In a PCR approach, with primers to the MMTV ORF and hybridization to MMTV specific probes, we have identified three human sequences. Direct sequencing of PCR products revealed that one of these products is related to a human autoantigen that is conserved among many species and is expressed in testes and sperm. The second sequence that we have identified is novel, and no evidence for expression of this sequence could be obtained. Finally, the third ORF-like sequence is a new member of a previously described family of human endogenous retroviruses (RTVL-I). This sequence is transcribed in several human cell lines, including B lymphoblastoid cells, and is thus the first demonstration that an RTVL-I-related sequence can be expressed. Taken together, these findings raise the intriguing possibility that the human genome contains superantigen-like sequences, some of which are also related to endogenous ...Continue Reading

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Citations

Jan 1, 1997·Journal of Biomedical Science·H.B. Rasmussen
Apr 23, 1999·Journal of Reproductive Immunology·V L Scofield
Jun 14, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hai LiVincent K Tsiagbe
Jan 1, 1997·Acta Neurologica Scandinavica. Supplementum·H B Rasmussen, J Clausen
Sep 14, 2014·The Journal of General Virology·Brian SalmonsWalter H Günzburg
Jan 1, 2010·Cancers·James S Lawson, Benjamin Heng
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C HohenadlV Erfle
Dec 1, 2005·Expert Opinion on Pharmacotherapy·Pedro F Escobar, Peter G Rose

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