Identification of transcription factors at the site of implantation in the later stages of murine pregnancy

Reproduction : the Official Journal of the Society for the Study of Fertility
Baohui ZhaoKathleen E Bethin

Abstract

Despite medical advances, preterm delivery continues to complicate 12% of all births in the United States and is a major cause of neonatal deaths. One of the reasons that preterm labor continues to be a significant problem is that very little is understood about the factors involved in normal labor. Many investigators have studied parturition in the mouse and defined essential pathways for normal labor. Prostaglandins play an essential role in mouse labor and are important in human labor as well. We examined the 23 transcription factors from pregnant mouse uterus that change expression after the induction of cyclooxygenase-1, the enzyme that catalyzes the first committed step in prostaglandin synthesis. Using in situ hybridization, we have identified three of these transcription factors, Hoxa10, Hoxa11 and GILZ as being expressed in the decidua and regulated at the end of pregnancy. Both Hoxa10 and Hoxa11 are known to be critical for implantation, but very little is known about their roles in late gestation. GILZ has not previously been identified in the gravid uterus. In summary, we have identified three transcription factors that are regulated in the decidua at the end of pregnancy, suggesting a role in detachment of the fetu...Continue Reading

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Citations

Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·G B GodboleC P Puri
Nov 11, 2008·Reproduction in Domestic Animals = Zuchthygiene·B GuoZ-P Yue
Apr 7, 2018·Environmental Health Perspectives·Shannon D WhirledgeJohn A Cidlowski
Jul 26, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Svetlana VujovićAndrea Ricardo Genazzani
Jul 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emira Ayroldi, Carlo Riccardi

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