Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis

American Journal of Respiratory Cell and Molecular Biology
Anne-Marie PulichinoCamil E Sayegh

Abstract

Lung fibrosis is characterized by excessive accumulation of extracellular matrix components leading to progressive airflow limitation. Distinct profibrotic pathways converge on the activation of transforming growth factor-beta (TGF-beta), a central growth factor implicated in most fibroproliferative diseases. Recently, enforced expression of bioactive human TGF-beta1 (hTGF-beta1) in lungs of transgenic mice was shown to recapitulate several key pathophysiologies observed in fibrotic disorders of the lung, including cellular inflammation, tissue fibrosis, and myofibroblast hyperplasia. Inducible expression of hTGF-beta1 in this system provided a unique opportunity to characterize TGF-beta-driven mechanisms that precede and/or follow the onset of inflammation and fibrosis. Using gene expression profiling in lungs, we demonstrate temporal activation of key genetic programs regulating cell movement and invasiveness, inflammation, organ remodeling, and fibrosis. Consistent with our gene expression data, multiple soluble mediators associated with inflammation and tissue remodeling were markedly elevated in the bronchoalveolar lavage fluid of mice expressing hTGF-beta1. We observe significant TGF-beta1-driven infiltration of F4/80+ mo...Continue Reading

References

Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S T UhD W Riches
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·N KaminskiR A Heller
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·G BorzoneC Lisboa
Jun 20, 2001·The Journal of Clinical Investigation·J F PittetD Sheppard
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Naoki ItanoKoji Kimata
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fengrong ZuoRenu A Heller
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Aug 2, 2003·Developmental Immunology·Geert RaesG H G Hassanzadeh
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murry W Wynes, David W H Riches
Apr 6, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ichiro InoshimaNobuyuki Hara
Apr 13, 2004·Journal of Leukocyte Biology·Paul AndersonNancy Kedersha
May 12, 2004·The Journal of Experimental Medicine·Nicolas ReymondMarc Lopez
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Shen-Wu WangZhengbin Yao
Apr 2, 2005·The European Respiratory Journal·A CapelliC F Donner
Sep 17, 2005·American Journal of Respiratory and Critical Care Medicine·Moises SelmanAlbert Zlotnik
Sep 28, 2005·Expert Opinion on Investigational Drugs·Fabio L M RicciardoloHerman Meurs
Jan 5, 2006·Critical Reviews in Immunology·Michael P KeaneJohn A Belperio
Jan 18, 2006·American Journal of Respiratory and Critical Care Medicine·Antje PrasseGernot Zissel
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Teresa PisabarroKerstin N Schmidt
Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Bethany B MooreGalen B Toews
Mar 23, 2006·Annual Review of Immunology·Ming O LiRichard A Flavell
Mar 30, 2006·Current Rheumatology Reports·Timothy E QuanRichard Bucala
May 20, 2006·American Journal of Respiratory Cell and Molecular Biology·Ana L MoraArlene Stecenko
Jun 2, 2006·Proceedings of the American Thoracic Society·Annie Pardo, Moisés Selman
Jun 27, 2006·Proceedings of the American Thoracic Society·Paul W Noble, Dianhua Jiang
Jun 27, 2006·Proceedings of the American Thoracic Society·Chun Geun LeeJack A Elias
Jun 30, 2006·The Journal of Biological Chemistry·Amy C CookAlan B Tuck
Aug 15, 2006·Journal of Leukocyte Biology·Justin P EdwardsDavid M Mosser
Sep 26, 2006·Mutation Research·Chantal Rodgarkia-DaraMichael Grusch
Dec 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salvatore CuzzocreaCarlo Riccardi
Mar 3, 2007·The Journal of Clinical Investigation·Thomas A Wynn

❮ Previous
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Citations

Jan 9, 2009·Mucosal Immunology·M S Wilson, T A Wynn
Feb 24, 2011·The Journal of Biological Chemistry·George PeridesMichael L Steer
Jul 13, 2011·Journal of Allergy·Renée C BensonClaudia R Morris
Mar 26, 2013·American Journal of Respiratory Cell and Molecular Biology·Bethany B MooreCory M Hogaboam
Jul 17, 2009·Journal of Leukocyte Biology·Robert D StoutJill Suttles
Oct 27, 2011·PloS One·Miguel Angel Alejandre AlcázarJörg Dötsch
Oct 5, 2010·Annual Review of Pharmacology and Toxicology·Debra L LaskinJeffrey D Laskin
Mar 19, 2016·Cell Death and Differentiation·S ChenT Stoeger
Sep 22, 2015·Frontiers in Medicine·Bram PiersmaMiriam Boersema
Apr 18, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jingjing ChenXiulan Zhao
Jan 9, 2010·Toxicology and Industrial Health·Xin WangJie Chen
Dec 28, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Debra L LaskinJeffrey D Laskin
May 23, 2014·The Korean Journal of Internal Medicine·Chang-Min LeeChun Geun Lee
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Diana ÁlvarezMauricio Rojas
Jan 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Manabu UenoMasahiko Kurabayashi
Jun 15, 2013·Alcoholism, Clinical and Experimental Research·Paul ThevenotStephania A Cormier
Sep 9, 2008·International Journal of Cancer. Journal International Du Cancer·Olivier De WeverMarc Bracke
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuei Liong LinJeremy S Duffield
Feb 15, 2013·Experimental and Therapeutic Medicine·Xianglin DongYing Cen
Dec 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Seung Jung KimSung Hwan Ki
Mar 9, 2021·Frontiers in Immunology·Federica MaccarinelliRoberto Ronca
Jun 3, 2011·Archives of Pathology & Laboratory Medicine·Robert J HomerErica Herzog
Dec 9, 2009·Toxicology Letters·Yaw-Dong LangChung-Ming Chen
Jul 14, 2010·Seminars in Nephrology·Jeremy S Duffield

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