Identification of tRNA-derived small noncoding RNAs as potential biomarkers for prediction of recurrence in triple-negative breast cancer

Cancer Medicine
Wanting FengYongmei Yin

Abstract

Triple-negative breast cancer (TNBC), an intrinsic subtype of breast cancer, is characterized by aggressive pathology and shorter overall survival. Yet there is no effective therapy for these patients. Breast cancer stem cells (BCSCs) in TNBC may account for treatment failure. It is urgent to identify new therapeutic targets for TNBC. tRNA-derived small noncoding RNAs (tDRs) represent a new class of small noncoding RNAs (sncRNA), which have been reported in some human diseases and biological processes. However, there is no detailed information about the relationship between tDRs and BCSCs. In this study, a population of CD44+ /CD24-/low cells was isolated and identified by reliable BCSC surface markers. tDR expression profiles in TNBC and non-TNBC CSCs were performed by RNA sequencing. A total of 1327 differentially expressed tDRs contained 18 upregulated and 54 downregulated in TNBC group. Furthermore, the selected tDRs were validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). tDR-000620 expression level was consistently lower in TNBC cell lines CSCs (all P < 0.05) and serum samples (t = 2.597, P = 0.013). tDR-000620 expression was significant association with age (P = 0.018), node status (P = 0...Continue Reading

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Citations

Nov 19, 2019·Database : the Journal of Biological Databases and Curation·Alessandro La FerlitaAlfredo Pulvirenti
Feb 20, 2020·RNA Biology·Juan Pablo Tosar, Alfonso Cayota
Nov 5, 2019·Frontiers in Oncology·Sangita SridharanDayanidhi Raman
Nov 21, 2020·Environmental and Molecular Mutagenesis·Yanbin ShiLin Ye
Jan 12, 2021·Molecular Carcinogenesis·Naing L ShanNanjoo Suh
May 25, 2021·Seminars in Cancer Biology·Jiao LiYong Peng
Aug 4, 2021·Aging and Disease·Ya YuanDeying Yang

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Methods Mentioned

BETA
PCR
flow cytometry
MDA

Software Mentioned

SPSS

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