Identification of Two Distinct Working Memory-Related Brain Networks in Healthy Young Adults

ENeuro
Tobias EgliAnnette Milnik

Abstract

Working memory (WM) is an important cognitive domain for everyday life functioning and is often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies in humans show that distributed brain areas typically described as fronto-parietal regions are implicated in WM tasks. Based on data from a large sample of healthy young adults (N = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal and identified two distinct networks that were relevant for differences in individual WM task performance. A parietally-centered network was particularly relevant for individual differences in task measures related to WM performance ("WM dependent") and a frontally-centered network was relevant for differences in attention-dependent task performance. Importantly, frontal areas that are typically considered as key regions for WM were either involved in both WM-dependent and attention-dependent performance, or in attention-dependent performance only. The networks identified here are provided as publicly available datasets. These networks can be applied in future studies to derive a low-dimensional representation of the overall WM brain activation.

Citations

Feb 2, 2021·Neuropsychology Review·Ari Alex Ramos, Liana Machado
Feb 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Stavros I DimitriadisDavid E Linden
Apr 6, 2021·Behavioural Brain Research·Jana PetrovskaAnnette Milnik
Nov 7, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Katarzyna JurewiczAndrzej Wróbel

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Methods Mentioned

BETA
contraception
PCA

Software Mentioned

GRAPPA
nifti
FreeSurfer
oro
fslr
fastICA
FSL
NiftyReg
SPM8
DARTEL

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