Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties.

Proceedings of the National Academy of Sciences of the United States of America
Eric T ClambeyPhilippa Marrack

Abstract

CD8 memory T cells are tightly regulated in young, healthy individuals but are often perturbed in aged animals by the appearance of large CD8 T cell clones. These clones are associated with impaired immunity in the aged. The molecular basis of this phenomenon remains unclear. Here, it is shown that the issue is confused by the fact that the clones are heterogeneous. Some clones bear high, and others, low levels of integrin alpha(4) (itgalpha4). These subtypes differ by multiple criteria. They appear in mice of different ages, concentrate in different tissues, and have different stabilities in vivo and responses to stimulation in vitro. itgalpha4(high), but not itgalpha4(low), CD8 clonal expansions have several characteristics consistent with a chronically stimulated phenotype. These properties include lowered levels of CD8, decreased expression of some cytokine receptors, and elevated expression of various inhibitory receptors, including the programmed death-1 (PD1) receptor and the killer cell lectin-like receptor G1 (KLRG1). The characteristics of itgalpha4(high) clonal expansions suggest that they may arise from age-dependent alterations in antigen expression and tolerance. These data redefine CD8 clonal expansions into at l...Continue Reading

References

Nov 1, 1991·The Journal of Experimental Medicine·H von BoehmerB Rocha
Feb 29, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·W D ChamberlainB L Kotzin
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J LeMaoultJ Nikolich-Zugich
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C C KuP Marrack
May 23, 2001·Current Biology : CB·O LechnerJ Buer
Mar 27, 2002·Nature Reviews. Immunology·Katia Georgopoulos
May 11, 2002·Nature Reviews. Immunology·Susan M KaechRaft Ahmed
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Saurwein-TeisslBeatrix Grubeck-Loebenstein
Dec 10, 2002·Annual Review of Immunology·Ronald H Schwartz
Apr 2, 2003·Nature Reviews. Immunology·Allan McI Mowat
Jul 4, 2003·Nature·J Rodrigo MoraUlrich H Von Andrian
Jul 30, 2003·European Journal of Immunology·Christina BartholdyAllan Randrup Thomsen
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle C GoldAnn B Hill
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·E John WherryRafi Ahmed
Nov 17, 2004·The Journal of Experimental Medicine·Ilhem MessaoudiJanko Nikolich-Zugich
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert MaileJeffrey A Frelinger
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilhem MessaoudiJanko Nikolich-Zugich
Apr 4, 2006·Trends in Immunology·J Rodrigo Mora, Ulrich H von Andrian
Jul 5, 2006·The Journal of Experimental Medicine·Onur BoymanJonathan Sprent
Jul 11, 2006·Immunological Reviews·Charles D SurhJonathan Sprent
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilhem MessaoudiJanko Nikolich-Zugich

❮ Previous
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Citations

Nov 14, 2012·Nature Reviews. Nephrology·Dianne McKay, Julie Jameson
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Christian S HinrichsNicholas P Restifo
Sep 20, 2011·The Journal of Clinical Investigation·Xi WangCharles W M Roberts
Mar 5, 2013·The Journal of Clinical Investigation·Encarnacion Montecino-RodriguezKenneth Dorshkind
Mar 12, 2013·Experimental Gerontology·Jiu JiangDonna M Murasko
Feb 27, 2013·Journal of Leukocyte Biology·Douglas V DolfiE John Wherry
Jun 10, 2011·Current Opinion in Immunology·Marcia A Blackman, David L Woodland
Aug 24, 2010·Ageing Research Reviews·Stefan BrunnerBeatrix Grubeck-Loebenstein
Jun 9, 2009·Current Opinion in Immunology·Laura Haynes, Alexander C Maue
Jul 3, 2009·Current Opinion in Immunology·Janet E McElhaney, Rita B Effros
Apr 20, 2010·Journal of the American Geriatrics Society·Kevin P HighKenneth E Schmader
Jan 13, 2010·Immunity·Stephen C Jameson, David Masopust
May 30, 2019·Immunology and Cell Biology·Tabinda Hussain, Kylie M Quinn
Feb 13, 2020·Cardiovascular Research·Xiao-Xi PanPing-Jin Gao
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luka Cicin-SainJanko Nikolich-Zugich
Jan 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vilma DecmanE John Wherry
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vilma DecmanE John Wherry
May 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Harumichi IshigameRichard A Flavell
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristel ArchambaudMarie Malissen
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacob E KohlmeierDavid L Woodland
Oct 27, 2020·Frontiers in Immunology·Mengyue WuXia Liu
Sep 11, 2020·Mechanisms of Ageing and Development·Akanksha PanwarChristopher J Wheeler
May 11, 2021·Frontiers in Immunology·Jayashree SrinivasanEllen R Richie

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