Identification of two novel antioxidant peptides from edible bird's nest (Aerodramus fuciphagus) protein hydrolysates

Food & Function
Masomeh GhassemAbdul Salam Babji

Abstract

Edible bird's nest (EBN) is widely consumed as a delicacy and traditional medicine amongst the Chinese. In the present study, for the first time, the antioxidant properties of an EBN pepsin-trypsin hydrolysate of the swiftlet species Aerodramus fuciphagus and its ultrafiltration fractions were investigated. Thirteen peptides with molecular weights between 514.29 and 954.52 Da were identified in the EBN fraction with the use of mass spectrometry. Two novel pentapeptides Pro-Phe-His-Pro-Tyr and Leu-Leu-Gly-Asp-Pro, corresponding to f134-138 and f164-168 of cytochrome b of A. fuciphagus, indicated the highest ORAC values of 14.95 and 14.32 μM of TE μM(-1) peptide, respectively. Both purified peptides showed resistance against simulated gastrointestinal proteases. In addition, both peptides had no in vitro cytotoxicity on human lung MRC-5 cells and prevented human liver carcinoma HepG2 cellular damage caused by hydroxyl radicals. Therefore, it is suggested that EBN protein hydrolysates are a good source of natural antioxidants and could be applied as nutraceutical compounds.

References

Jun 9, 2001·The Journal of Allergy and Clinical Immunology·D L GohB W Lee
Sep 30, 2004·Journal of Food Protection·A DávalosR López-Fandiño
Apr 4, 2006·Antiviral Research·Chao-Tan GuoYasuo Suzuki
Jun 24, 2010·Journal of Agricultural and Food Chemistry·Shengwen ShenJianping Wu
Mar 11, 2011·Bioscience, Biotechnology, and Biochemistry·Noriko MatsukawaTakamitsu Tsukahara
Jul 28, 2012·International Journal of Molecular Sciences·Kim Wei ChanMaznah Ismail
Dec 25, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María José García-NebotBlanca Hernández-Ledesma
Oct 14, 2014·BMC Complementary and Alternative Medicine·Mei Yeng YewKhuen Yen Ng
Aug 15, 2015·Journal of Diabetes Research·Zhang YidaNorhayati Binti Yusuf

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Citations

Jul 7, 2020·Journal of Food Science and Technology·Muhamad Hanif RawiShahrul Razid Sarbini
Feb 18, 2021·Food & Function·Wenjing ChenJihong Huang
Mar 3, 2021·Food Research International·Yuwei DaiLin Jiang

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