Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasis

Arthritis and Rheumatism
Hsiang-Chi MengPércio S Gulko

Abstract

To identify additional sex-specific and epistatic quantitative trait loci (QTL) regulating collagen-induced arthritis (CIA) severity overall, as well as within different stages during the disease course, in an intercross between major histocompatibility complex-identical inbred rat strains DA/Bkl (susceptible) and ACI/Hsd (resistant). Arthritic male (DA x ACI)F2 intercross offspring (n = 143) were analyzed separately from the females (n = 184). Phenotypic extremes (maximum arthritis scores [MAS]) were genotyped and used for QTL analysis. All 327 rats were genotyped with the simple sequence-length polymorphism (SSLP) markers closest to the peak of Cia7 and Cia10, the major loci previously identified in this intercross, and with SSLPs covering chromosomes 12 and 18. Phenotypes studied were disease onset, arthritis severity scores on days 14-39, MAS, mean and cumulative arthritis scores, delayed-type hypersensitivity, and antibody responses to rat type II collagen. A new female-specific arthritis-severity recessive locus was identified on rat chromosome 12 (Cia25), with a maximum effect observed on day 28 (logarithm of odds [LOD] 4.7). The homozygous DA genotype at Cia25 was associated with a 45% higher median arthritis score in f...Continue Reading

References

Nov 1, 1992·Genomics·S E Lincoln, E S Lander
Jul 1, 1992·Genetics·T SerikawaG M Lathrop
Jan 1, 1995·Nature Genetics·H J JacobA Lernmark
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·D H KonoA N Theofilopoulos
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E F RemmersR L Wilder
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A Darvasi
May 1, 1997·Genome Research·M T BihoreauG M Lathrop
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C LorentzenH Luthman
Jul 10, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D M BrownH J Jacob
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·K G BeckerJ M Trent
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·F CornélisUNKNOWN ECRAF
Jan 14, 1999·International Immunology·S ShiozawaS Imura
Mar 24, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S ListwakE M Sternberg
Jun 12, 1999·Arthritis and Rheumatism·M F SeldinP K Gregersen
Aug 12, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L S KlaffA Lernmark
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BergsteinsdottirR Holmdahl
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E P BlankenhornC Teuscher
Apr 14, 2000·American Journal of Human Genetics·B VaidyaS H Pearce
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J M OttoT T Glant
Jan 31, 2002·Arthritis and Rheumatism·Peter OlofssonRikard Holmdahl

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Citations

Aug 1, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carola Rintisch, Rikard Holmdahl
Sep 10, 2005·Annals of the Rheumatic Diseases·M BrennerP S Gulko
Mar 3, 2007·Annals of the Rheumatic Diseases·Max BrennerPércio S Gulko
May 31, 2014·Mediators of Inflammation·Jianlu WeiChuanju Liu
Dec 20, 2012·Clinical & Developmental Immunology·Timea BesenyeiZoltan Szekanecz
Oct 19, 2011·Arthritis and Rheumatism·Elena KudryavtsevaVyacheslav A Adarichev
Sep 29, 2012·Journal of Pharmacological Sciences·Yuko KanasakiHideto To
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Bernd U KoelschAndrea Kindler-Röhrborn
Jun 29, 2006·Physiological Genomics·Bina Joe
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qing XiongWeikuan Gu

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