Identification of two pseudogenes with sequence homology to human and gorilla MHC class IA genes: ancestral haplotype in the Filipino population

Human Immunology
G CoquillardS G Rodriguez-Marino

Abstract

While characterizing exons 2 and 3 of the class I human leukocyte antigen (HLA)-A locus in human lymphocytes, two similar but unexpected PCR products were detected in six samples of Filipino ethnicity. A nucleotide sequence analysis of the two amplicons, tentatively named HLA-COQ and HLA-DEL, rendered them as two novel and seemingly related sequences, both with homology to the gorilla and human major histocompatibility complex (MHC) A locus. Exon 2 is similar to the published human pseudogenes HLA-BEL, HLA-Y, and to primate MHC Gogo-A*0501, differing by 2 bp from HLA-BEL, and HLA-Y, and by 4 bp from Gogo-A*0501. Exon 3 is most similar to HLA-A*2902 and A*310102, differing by 7 bp from A*2902, and by 8 bp from A*31012. Genomic sequence comparison of exons 1 to 8 indicates that their closest published match is to the Gogo-A*0501. Complete typing at the HLA-A, -B, -C, DRB1, and DRB5 loci for the six samples yielded the reoccurring types: HLA-A*3401, -B*1521/1525, -Cw*0403, -DRB1*150201, and DRB5*010101. Thus far, HLA-COQ and HLA-DEL have been detected only in Filipino samples containing these HLA types. The HLA-COQ gene is nonfunctional based on a stop codon located in exon 4. HLA-DEL is also a nonfunctional gene because of the du...Continue Reading

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Citations

Jun 7, 2005·Human Immunology·Wendy T N SwelsenElla M van den Berg-Loonen
May 28, 2005·Current Rheumatology Reports·Bruce M Rothschild
Sep 23, 2010·Human Immunology·Christina E M VoorterMarcel G J Tilanus
Apr 2, 2010·Tissue Antigens·S G E MarshJ Trowsdale
Mar 24, 2017·Immunogenetics·Jörg B HansLinda Vigilant
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael GleimerPeter Parham
Mar 7, 2019·Frontiers in Immunology·Emily E WroblewskiLisbeth A Guethlein

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