PMID: 16640327DOI: 10.1021/jm051225tApr 28, 2006Paper
Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target
Journal of Medicinal Chemistry
Curtis R ChongJun O Liu
Abstract
To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.
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