Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Rui-Hua DongZe-Yuan Liu

Abstract

1. Carvacrol (2-methyl-5-(1-methylethyl)-phenol), one of the main components occurring in many essential oils of the family Labiatae, has been widely used in food, spice and pharmaceutical industries. 2. The carvacrol glucuronidation was characterized by human liver microsomes (HLMs), human intestinal microsomes (HIMs) and 12 recombinant UGT (rUGT) isoforms. 3. One metabolite was identified as a mono-glucuronide by liquid chromatography/mass spectrometry with HLMs, HIMs, rUGT1A3, rUGT1A6, rUGT1A7, rUGT1A9 and rUGT2B7. 4. The study with a chemical inhibition, rUGT, and kinetics study demonstrated that rUGT1A9 was the major isozyme responsible for glucuronidation in HLMs, and rUGT1A7 played a major role for glucuronidation in HIMs.

References

Aug 1, 1987·Pharmacology & Toxicology·L T AustgulenR R Scheline
Jun 9, 1999·The Biochemical Journal·G JedlitschkyB Burchell
Jul 24, 2001·Current Drug Metabolism·C D KingT R Tephly
Jan 17, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Laurence AntonioJacques Magdalou
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Soundararajan KrishnaswamyMichael H Court
Apr 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David TurgeonAlain Bélanger
Jul 20, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Soundararajan KrishnaswamyMichael H Court
Nov 30, 2004·Fitoterapia·M De VincenziM Silano
Sep 6, 2005·Pharmacogenetics and Genomics·Peter I MackenzieDaniel W Nebert
Sep 21, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Oranun KerdpinJohn O Miners
May 16, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Akiko NakamuraTsuyoshi Yokoi
Dec 17, 2008·Current Pharmaceutical Design·K Husnu Can Baser
Aug 5, 2009·Fundamental & Clinical Pharmacology·Balakrishnan AristatileKodukkur Viswanathan Pugalendi
Nov 7, 2009·International Journal of Food Microbiology·A M MennitiF Neri
Feb 24, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Si-Cheng LiangLing Yang
May 12, 2010·International Journal of Food Microbiology·Kavitha Palaniappan, Richard A Holley

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Citations

Mar 19, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Bo TanYizhun Zhu
Jul 21, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Rui-Hua DongZe-Yuan Liu
Mar 13, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Bao-Li MiZhen-Qiu Zhang
Nov 10, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Llana-Ruiz-CabelloAna M Cameán

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