Abstract
Glioblastoma (GBM) is one of the most common highly malignant primary brain tumor with poor prognosis. This study aimed to explore the possible mechanism by bioinformatics method and detect potential function of UGP2 of GBM. Gene expression microarray data of GSE4412 and messenger RNA-sequencing data of GBM with samples clinical information were downloaded from the Gene Expression Omnibus database and The Cancer Genome Atlas database, respectively. Differentially expressed genes (DEGs) analysis using the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology based on R language. A total of 1000 common DEGs were identified in GBM samples, including 353 upregulated and 647 downregulated genes. Based on the random survival forest model, we identified UDP-glucose pyrophosphorylase 2 (UGP2) (upregulated gene) had a significant effect on GBM prognosis. Functional enrichment showed that UGP2 was enriched in the biological progresses of cell proliferation, migration, and invasion. Furthermore, UGP2 expression is aberrantly overexpressed in human glioma and positively correlated with pathologic grade. A loss-of-function study showed that knockdown of UGP2 decreases U251 cell growth, migration, and invasion in vivo and vitro. We propo...Continue Reading
References
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Sep 18, 2004·Cancer Research·William A FreijeStanley F Nelson
Mar 6, 2012·Molecular Aspects of Medicine·Hartwig WolburgKaren Wolburg-Buchholz
Apr 18, 2012·Genes & Development·Gavin P DunnWilliam C Hahn
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Antonio Omuro, Lisa M DeAngelis
Jan 25, 2014·Nature Reviews. Cancer·Dominik SturmStefan M Pfister
May 13, 2014·Nature·Chioniso P MasamhaEric J Wagner
Sep 2, 2014·Advanced Drug Delivery Reviews·Andrew RapeSanjay Kumar
Oct 15, 2014·EMBO Molecular Medicine·Steven K CarlssonClaes Wahlestedt
Mar 13, 2015·Nature·Duane A MitchellJohn H Sampson
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chris WilliamsIda J van der Klei
May 7, 2015·Pharmacology & Therapeutics·Constantinos Alifieris, Dimitrios T Trafalis
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruno Kovic, Feng Xie
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Jun 30, 2015·Molecular Aspects of Medicine·Keon MahmoudiCostas Hadjipanayis
Jul 9, 2016·Cancer Investigation·Qunwei WangSenlin Chen
Dec 14, 2016·The New England Journal of Medicine·Aden K ChanHo-Keung Ng
Feb 2, 2017·The Journal of Clinical Investigation·Satoru Osuka, Erwin G Van Meir
Jul 5, 2017·Nature Reviews. Clinical Oncology·Hui K GanAndrew M Scott
Aug 13, 2017·Lancet·Martin J van den BentJohan M Kros
Oct 17, 2017·Nature Medicine·Wilson X MaiDavid A Nathanson
Nov 5, 2017·Oncotarget·Li YinCunshuan Xu
Apr 13, 2018·Nature Reviews. Clinical Oncology·Michael LimMichael Weller
Jul 10, 2018·Nature Reviews. Neurology·Marike L BroekmanXandra O Breakefield
Aug 4, 2018·Trends in Molecular Medicine·Mark C de GooijerOlaf van Tellingen
Citations
Dec 31, 2019·Journal of Cellular Biochemistry·Yao JiangYiqin Li
May 5, 2020·Briefings in Bioinformatics·Mengying ZhangXia Li
Aug 1, 2020·Disease Markers·Qiuyue HuGuangying Cui
Mar 18, 2020·International Journal of Molecular Sciences·Arabel Vollmann-ZwerenzPeter Hau
Dec 11, 2019·Acta Neuropathologica·Elena PerenthalerTahsin Stefan Barakat
May 2, 2021·Molecular Oncology·Mohammad SultanPaola Marcato
Jun 1, 2021·ACS Omega·Sonia PodvinVivian Hook
Aug 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Andrew L WolfeSung Eun Kim
Oct 9, 2021·Frontiers in Pharmacology·Yanbo FengJinghui Sun