Identification of variable stages in murine pancreatic tumors by a multiparametric approach employing hyperpolarized 13 C MRSI, 1 H diffusivity and 1 H T1 MRI.

NMR in Biomedicine
Ricardo P MartinhoLucio Frydman

Abstract

This study explored the usefulness of multiple quantitative MRI approaches to detect pancreatic ductal adenocarcinomas in two murine models, PAN-02 and KPC. Methods assayed included 1 H T1 and T2 measurements, quantitative diffusivity mapping, magnetization transfer (MT) 1 H MRI throughout the abdomen and hyperpolarized 13 C spectroscopic imaging. The progress of the disease was followed as a function of its development; studies were also conducted for wildtype control mice and for mice with induced mild acute pancreatitis. Customized methods developed for scanning the motion- and artifact-prone mice abdomens allowed us to obtain quality 1 H images for these targeted regions. Contrasts between tumors and surrounding tissues, however, were significantly different. Anatomical images, T2 maps and MT did not yield significant contrast unless tumors were large. By contrast, tumors showed statistically lower diffusivities than their surroundings (≈8.3 ± 0.4 x 10-4 for PAN-02 and ≈10.2 ± 0.6 x 10-4 for KPC vs 13 ± 1 x 10-3 mm2 s-1 for surroundings), longer T1 relaxation times (≈1.44 ± 0.05 for PAN-02 and ≈1.45 ± 0.05 for KPC vs 0.95 ± 0.10 seconds for surroundings) and significantly higher lactate/pyruvate ratios by hyperpolarized 13 ...Continue Reading

References

May 4, 2001·European Journal of Radiology·F ObuzS Karademir
Oct 19, 2001·Journal of Clinical Gastroenterology·S R PrasadS Saini
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Jan GrimmAnna Moore
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Klaes GolmanIb Leunbach
Feb 24, 1956·Science·O WARBURG
Aug 10, 2006·Journal of Magnetic Resonance Imaging : JMRI·Denis Le BihanFranck Lethimonnier
Sep 21, 2006·AJR. American Journal of Roentgenology·Frank H MillerAna L Keppke
Apr 17, 2007·NeuroImage·Helen D'Arceuil, Alex de Crespigny
Feb 28, 2008·Topics in Magnetic Resonance Imaging : TMRI·Wolfgang SchimaClaus Koelblinger
Mar 19, 2009·Biochemical and Biophysical Research Communications·Catherine CarrièreMurray Korc
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timothy M ShepherdStephen J Blackband
Jul 30, 2010·Progress in Nuclear Magnetic Resonance Spectroscopy·Assaf Tal, Lucio Frydman
Mar 16, 2011·Neoplasia : an International Journal for Oncology Research·John KurhanewiczCraig R Malloy
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weiguo LiAndrew C Larson
May 25, 2012·Radiology·Yoshihiko FukukuraMasayuki Nakajo
Aug 17, 2012·Annals of Surgery·Katherine E PorukSean J Mulvihill
Apr 9, 2013·Journal of Magnetic Resonance·Eddy SolomonLucio Frydman
May 15, 2013·World Journal of Radiology·Eric Peter TammAparna Balachandran
Aug 8, 2013·World Journal of Gastroenterology : WJG·Zhen WangYuan Huang
Oct 24, 2013·AJR. American Journal of Roentgenology·Kumaresan SandrasegaranGregory A Cote
Jul 1, 2014·World Journal of Gastroenterology : WJG·Eun Sun Lee, Jeong Min Lee
Jul 30, 2014·World Journal of Gastroenterology : WJG·Yong-Jian JiangDe-Liang Fu
Aug 26, 2014·World Journal of Gastroenterology : WJG·Ahmet Bilici
Dec 31, 2014·PloS One·Noam NissanHadassa Degani
Nov 5, 2015·Cancer Discovery·Rushika M Perera, Nabeel Bardeesy
Jan 12, 2016·World Journal of Radiology·Meng-Yue TangXiao-Hua Huang
Apr 27, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teresa A Brentnall
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Caroline GuglielmettiMyriam M Chaumeil
Oct 14, 2017·World Journal of Methodology·Ting YinYicheng Ni
Feb 15, 2018·Circulation Research·Andrew J M LewisDamian J Tyler
Mar 15, 2018·Journal of Magnetic Resonance Imaging : JMRI·Min WangYu Shi
May 23, 2018·World Journal of Gastroenterology : WJG·Lulu ZhangAlina Stoita
Nov 1, 2018·Magnetic Resonance Imaging Clinics of North America·Priyanka JhaZhen J Wang
Nov 10, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ravneet VohraDonghoon Lee
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 18, 2019·Chronic Diseases and Translational Medicine·Sireesha UpadhrastaLei Zheng
Aug 2, 2019·Journal of Magnetic Resonance Imaging : JMRI·Hans Stødkilde-JørgensenBritta Weber
Jan 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qingjia BaoLucio Frydman

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