Identification of Wnt/β-catenin signaling pathway in dermal papilla cells of human scalp hair follicles: TCF4 regulates the proliferation and secretory activity of dermal papilla cell

The Journal of Dermatology
Ya XiongXi-chuan Yang

Abstract

It is clear that the dermal papilla cell (DPC), which is located at the bottom of the hair follicle, is a special mesenchymal component, and it plays a leading role in regulating hair follicle development and periodic regeneration. Recent studies showed that the Wnt signaling pathway through β-catenin (canonical Wnt signaling pathway) is an essential component in maintaining the hair-inducing activity of the dermal papilla and growth of hair papilla cells. However, the intrinsic pathways and regulating mechanism are largely unknown. In the previous work, we constructed a cDNA subtractive library of DPC and first found that the TCF4 gene, as a key factor of Wnt signaling pathway, was expressed as the upregulated gene of the hair follicle in low-passage DPC. This study was to explore the role of TCF4 in regulating the proliferation and secretory activity of DPC. We constructed a pcDNA3.0-TCF4 expression vector and transfected it into DPC to achieve stable expression by bangosome 2000. Furthermore, we used the method of chemosynthesis to synthesize three pairs of TCF4 siRNA and transfected them into DPC. Meanwhile, we compared the transfection group and non-transfection group. We first proposed that there was expression difference...Continue Reading

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Citations

Nov 10, 2013·PloS One·Jemima L WhyteJill A Helms
Jan 22, 2015·PloS One·Ksenia GnedevaAlexey V Terskikh
Aug 16, 2005·Current Opinion in Biotechnology·Kurt S Stenn, George Cotsarelis
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Sep 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Van-Long TruongWoo-Sik Jeong
Apr 24, 2019·Immunological Investigations·Fateme RajabiHamideh Moravvej
Sep 9, 2015·Cell Biology International·Yu ZhuangZhong-Xiang Yuan
Jul 16, 2020·International Journal of Molecular Sciences·Bu Young Choi
Mar 18, 2016·International Journal of Molecular Medicine·Li ZhangHong Wang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hwa Sun RyuYong-Moon Lee

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