PMID: 6166706Apr 1, 1981Paper

Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule

The Journal of Experimental Medicine
R Dalchau, J W Fabre

Abstract

Initial studies with the monoclonal antibody F8-11-13 described in this paper showed that it reacted strongly with B lymphocytes, did not react at all with granulocytes, and reacted only weakly with a small subpopulation of thymocytes and peripheral T lymphocytes. This picture was entirely different from that seen with monoclonal antibodies to the leukocyte common (LC) antigen, where 100% of all the above-mentioned leukocyte populations were positive. Biochemical studies using detergent solubilized membranes labeled with 3H at the sialic acid residues showed that the molecule bearing the F8-11-13 determinant was a glycoprotein of 215,000 mol wt, and that the peak depleted by F8-11-13 monoclonal antibody affinity columns corresponded to the high molecular weight region of a broad peak previously shown to be completely depleted by monoclonal antibody (F10-89-4) affinity columns directed at the LC antigen. Proof that the F8-11-13 determinant was expressed on some LC molecules was established by cross-inhibition studies with affinity-column-purified and depleted material. This finding of a serologically identifiable conformational or other structural change selectively expressed on the LC molecule of a functionally discrete populat...Continue Reading

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M KehryL E Hood
Mar 1, 1979·The Journal of Experimental Medicine·R Dalchau, J W Fabre
Aug 27, 1974·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C R Parish, J A Hayward
Oct 1, 1973·European Journal of Immunology·A F Williams
May 1, 1980·The Journal of Experimental Medicine·M B OmaryM P Scheid

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Citations

Jan 1, 1982·Immunogenetics·R HymanJ Trotter
Jan 1, 1983·Immunogenetics·J S TungM A Palladino
Jan 1, 1990·European Journal of Nuclear Medicine·R B RichardsonL S Lashford
Jan 1, 1984·Developmental and Comparative Immunology·K S Landreth, P W Kincade
Jan 15, 1986·Cancer Genetics and Cytogenetics·I JackA Morley
Oct 1, 1988·Immunology Today·M L Thomas, L Lefrançois
Nov 1, 1981·Human Immunology·A E BergerP Cresswell
Aug 1, 1993·Immunology and Cell Biology·B R Yacyshyn
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K S LandrethS M Fu
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S MiyataniT Tada
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A LedbetterE A Clark
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M L BirkelandE Puré
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W M GallatinE A Clark
Nov 1, 1981·The Journal of Experimental Medicine·I S Trowbridge, M B Omary
Dec 1, 1987·The Journal of Experimental Medicine·C E RuddS F Schlossman
Dec 1, 1990·British Journal of Haematology·M G Macey, A C Newland
May 1, 1983·Journal of Clinical Pathology·K C GatterD Y Mason
Mar 1, 1987·International Reviews of Immunology·P W KincadeG Lee
Aug 1, 1992·Pathology, Research and Practice·M WernerA Georgii
Jan 1, 1983·Immunology Today·I F McKenzie, H Zola
Jan 1, 1985·Leukemia Research·R SeshadriA A Morley
Aug 1, 1989·Clinical Immunology and Immunopathology·S J PirruccelloB M McManus

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