Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients

Frontiers in Immunology
Melissa J ConroyJoanne Lysaght

Abstract

The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key player in their active migration to this inflamed tissue. More recently, others have established that subsets of memory CD8+ T cells can be classified based on their surface expression of CX3CR1; the specific receptor for the inflammatory chemokine fractalkine. CD8+ T cells expressing intermediate levels (CX3CR1INT) are defined as peripheral memory, those expressing the highest levels (CX3CR1HI) are effector memory/terminally differentiated and those lacking CX3CR1 (CX3CR1NEG) are classified as central memory. To date, the fractalkine:CX3CR1 axis has not been examined in the context of CD8+ T cell enrichment in the omentum and here we examine this chemokines involvement in the accumulation of memory CD8+ T cells in the omentum of EAC patients. Our data show that fractalkine is significantly enriched in the omentum of EAC patients and drives migration of T cells derived from EAC patient blood. Furthermore, CX3CR1 is endocytosed specifically by CD8+ T cells upon encountering fractalkin...Continue Reading

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Citations

Sep 17, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Lina WangLi Wang
Jun 26, 2020·Frontiers in Oncology·Robert PowerMargaret R Dunne
Mar 6, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Maria E KavanaghJoanne Lysaght
Aug 6, 2019·Frontiers in Immunology·Rui Liu, Barbara S Nikolajczyk
Feb 9, 2021·Biochemistry and Biophysics Reports·Eun Jeong ParkMotomu Shimaoka
Jul 18, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ashanty M MeloMelissa J Conroy
Jul 30, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eimear MylodMelissa J Conroy

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Methods Mentioned

BETA
ELISA
GTPase
flow cytometry
Protein Assay

Software Mentioned

Prism GraphPad
FlowJo

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