Identifying a therapeutic window in acute and subacute inflammatory sensory neuronopathies

Journal of the Neurological Sciences
Jean-Christophe AntoineFrench Neuromuscular Network FILNEMUS

Abstract

Patients with inflammatory sensory neuronopathy (SNN) may benefit from immunomodulatory or immunosuppressant treatments if administered timely. Knowing the temporal profile of neuronal loss in dorsal root ganglia will help to ascertain whether a final diagnosis may be reached before the occurrence of irreversible neuronal injuries. Thus, we addressed the evolution of neuronal loss in SNN by using sensory nerve action potentials (SNAPs) as a surrogate marker of neuron degeneration. Eighty-six patients with acute/subacute inflammatory SNN (paraneoplastic, associated with dysimmune diseases, or idiopathic) were retrospectively studied. The monthly SNAP reduction was determined and normalized with the lower limit of normal. Disability progression was expressed by the modified Rankin score and correlated with SNAP reduction. The monthly SNAP reduction was similar in the four limbs although the median nerve was less severely affected. The monthly SNAP reduction was very severe within the first two months of evolution, began to slow down after seven months, and stabilized after ten months. It was tightly correlated with disability progression. Kaplan-Meier analysis showed that the median time until matching the diagnostic criteria of ...Continue Reading

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Citations

Jul 18, 2016·Journal of the Neurological Sciences·W GrisoldW N Löscher
May 10, 2019·BMJ : British Medical Journal·Kelly Graham Gwathmey, Kathleen T Pearson
Nov 7, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Yannick TholanceUNKNOWN anti-FGFR3 antibody Study Group
Jul 7, 2017·Current Opinion in Neurology·Jean-Christophe Antoine, Jean-Philippe Camdessanché
Jun 22, 2019·Journal of the Peripheral Nervous System : JPNS·Alberto R M MartinezMarcondes C França
Aug 25, 2017·Current Neurology and Neuroscience Reports·Allison Crowell, Kelly G Gwathmey
Oct 24, 2018·Journal for Immunotherapy of Cancer·Jaqueline GhosnMichel Obeid
Aug 1, 2019·Arquivos de neuro-psiquiatria·Alberto Rolim Muro MartinezMarcondes Cavalcante França
Oct 22, 2020·The New England Journal of Medicine·Anthony A Amato, Allan H Ropper
Feb 11, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Steve Vucic
Feb 11, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Guillaume Fargeot, Andoni Echaniz-Laguna

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