Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Pierre AebyPetra Winkler

Abstract

The sensitizing potential of chemicals is usually identified and characterized using one of the available animal test methods, such as the mouse local lymph node assay. Due to the increasing public and political concerns regarding the use of animals for the screening of new chemicals, the Colipa Skin Tolerance Task Force collaborates with and/or funds research groups to increase and apply our understanding of the events occurring during the acquisition of skin sensitization. Knowledge gained from this research is used to support the development and evaluation of novel alternative approaches for the identification and characterization of skin sensitizing chemicals. At present one in chemico (direct peptide reactivity assay (DPRA)) and two in vitro test methods (cell based assays (MUSST and h-CLAT)) have been evaluated within Colipa inter-laboratory ring trials and accepted by the European Centre for the Validation of Alternative Methods (ECVAM) for pre-validation. Data from all three test methods will be used to support the development of testing strategy approaches for skin sensitizer potency prediction. The replacement of the need for animal testing for skin sensitization risk assessment is viewed as ultimately achievable and ...Continue Reading

References

Nov 1, 1992·Contact Dermatitis·M R Upadhye, H I Maibach
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Aug 12, 1999·Clinical and Experimental Immunology·T RustemeyerR J Scheper
Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T AshikagaS Aiba
Mar 29, 2003·Regulatory Toxicology and Pharmacology : RTP·Susan P FelterG Frank Gerberick
Jan 8, 2004·The Journal of Investigative Dermatology·Norikatsu MizumotoAkira Takashima
Jul 16, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·G Frank GerberickJean-Pierre Lepoittevin
Dec 29, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L J LoretzC Sewall
Apr 9, 2005·The Journal of Investigative Dermatology·Norikatsu MizumotoAkira Takashima
Sep 13, 2005·Cytokine·C E M GriffithsI Kimber
Nov 29, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T AshikagaH Toyoda
Nov 30, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Morihiko Hirota, Osamu Moro
Dec 13, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H SakaguchiH Suzuki
Feb 4, 2006·The Journal of Investigative Dermatology·Marc VocansonJean-François Nicolas
Jun 15, 2006·Journal of Applied Toxicology : JAT·Ian R JowseyIan Kimber
Aug 22, 2006·Contact Dermatitis·David A BasketterPreya Kullavanijaya
Aug 22, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Linda LoretzSally Vater
Nov 23, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Masaaki MiyazawaHiroyuki Suzuki
Feb 20, 2007·Toxicology and Applied Pharmacology·François PythonPierre Aeby
Apr 3, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·G Frank GerberickJean-Pierre Lepoittevin
Feb 5, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L J LoretzC G Scrafford
Feb 28, 2008·The Journal of Toxicological Sciences·Masaaki MiyazawaNaohiro Nishiyama
May 22, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Montserrat MitjansEmanuela Corsini
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Corinna Tietze, Brunhilde Blomeke
Jul 4, 2008·The International Journal of Biochemistry & Cell Biology·Carmelo Luci, Elena Tomasello
Oct 30, 2008·Journal of Immunotoxicology·Nadege AdeFrancoise Rousset
Sep 15, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·G Frank GerberickJean-Pierre Lepoittevin
Jun 1, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hitoshi SakaguchiTakao Ashikaga

❮ Previous
Next ❯

Citations

Jun 19, 2012·Archives of Toxicology·Annette MehlingRobert Landsiedel
Jul 13, 2011·Journal of Allergy·Stacey E AndersonB J Meade
Mar 1, 2012·Cellular and Molecular Bioengineering·Nripen S SharmaMartin L Yarmush
Jul 12, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jenny HennenBrunhilde Blömeke
Jul 5, 2011·Immunopharmacology and Immunotoxicology·Yu-Ping CaoZi-Yi Chen
Mar 20, 2015·The Journal of Toxicological Sciences·Kyoko Tsujita-InoueHirokazu Kouzuki
Apr 19, 2012·Experimental Dermatology·Stefan F Martin
Apr 2, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrenoP Wolkenstein
Sep 27, 2014·International Journal of Cosmetic Science·C Stiefel, W Schwack
Jul 18, 2015·Veterinary Dermatology·Karen K HoSidonie N Lavergne
Feb 6, 2014·Journal of Applied Toxicology : JAT·Muriel Guyard-NicodèmeMarc G J Feuilloley
Jul 8, 2014·Critical Reviews in Toxicology·Jochem W van der VeenHenk van Loveren
Apr 15, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hendrik ReuterAndreas Schepky
Oct 4, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sebastian G KleinArno C Gutleb
Oct 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B ReesS Gibbs
Jul 17, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yuko NukadaNaohiro Nishiyama
Aug 29, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lisa DietzHermann-Josef Thierse
Jul 4, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V MartínezM Mitjans
Jan 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kazutoshi SaitoNaohiro Nishiyama
Aug 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Anne RichterStefan F Martin
Jun 26, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Marc TeunisSusan Gibbs
Oct 16, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Emanuela CorsiniMarina Marinovich
Mar 1, 2012·Regulatory Toxicology and Pharmacology : RTP·Carsten GoebelJulia Scheel
Jun 21, 2012·Regulatory Toxicology and Pharmacology : RTP·David BasketterJulia Scheel
Nov 28, 2013·Regulatory Toxicology and Pharmacology : RTP·Darrell R BoverhofYung Yang
Sep 24, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Roger EmterAndreas Natsch
Mar 29, 2013·Chemical Research in Toxicology·Tamara DelaineAnn-Therese Karlberg
Nov 23, 2011·Toxicologic Pathology·Robert Luebke
Dec 22, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erika ParkinsonPaul Skipp
May 2, 2018·Journal of Toxicology and Environmental Health. Part a·Daniela Morais LemeDanielle Palma de Oliveira
Mar 16, 2013·Annals of the New York Academy of Sciences·Myrtle DavisPaul B Watkins
Jan 7, 2020·Alternatives to Laboratory Animals : ATLA·Bianca MariglianiAnna Maria Buehler
Sep 5, 2012·Alternatives to Laboratory Animals : ATLA·Agnieszka Kinsner-OvaskainenValérie Zuang
Apr 12, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·U Blume-PeytaviR Dauskardt
May 26, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Elodie ClouetPierre-Jacques Ferret

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved