Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Sofia BouhlalLorenzo Leggio

Abstract

Sweet preference in individuals with alcohol use disorder (AUD) has been associated with family history of AUD and personality traits. Therefore, testing sweet preference may help identify subpopulations of AUD individuals. Sweet preference has been associated with family history of AUD and personality traits. We compared heavy drinkers based on their sweet liker status and using two cutoffs. Our findings support the role of sweet preference in heavy drinkers and point to the importance of how sweet likers are defined. This study aimed at describing and comparing heavy drinkers based on their sweet liker status, through demographic, neuroendocrine, inflammatory, behavioral and drinking characteristics. Participants rated the pleasantness and intensity of sucrose solutions (0.05, 0.10, 0.21, 0.42 and 0.83 M). Two cutoffs were used to identify likers versus dislikers: Grouping A likers preferred 0.83 M and Grouping B likers preferred 0.83 or 0.42 M; the rest were dislikers. Sweet likers were 36% (n = 20) using Grouping A and 58.2% (n = 32) using Grouping B. Grouping B, but not Grouping A, sweet likers had higher BMI (P = 0.01). In Grouping B, sweet likers had higher plasma leptin and insulin concentrations and higher insulin resi...Continue Reading

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Citations

Jun 4, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Patrick BachFalk Kiefer
Jan 29, 2021·Addiction Biology·Fernando EzquerYedy Israel
Feb 16, 2021·Neuroscience and Biobehavioral Reviews·Khushbu AgarwalPaule Valery Joseph
Jul 18, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Alexei Kampov-PolevoyJames C Garbutt
Oct 7, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Erika M RosenTekeda F Ferguson

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