Identifying and evaluating field indicators of urogenital schistosomiasis-related morbidity in preschool-aged children

PLoS Neglected Tropical Diseases
Welcome M WamiFrancisca Mutapi

Abstract

Several studies have been conducted quantifying the impact of schistosome infections on health and development in school-aged children. In contrast, relatively little is known about morbidity levels in preschool-aged children (≤ 5 years) who have been neglected in terms of schistosome research and control. The aim of this study was to compare the utility of available point-of-care (POC) morbidity diagnostic tools in preschool versus primary school-aged children (6-10 years) and determine markers which can be used in the field to identify and quantify Schistosoma haematobium-related morbidity. A comparative cross-sectional study was conducted to evaluate the performance of currently available POC morbidity diagnostic tools on Zimbabwean children aged 1-5 years (n=104) and 6-10 years (n=194). Morbidity was determined using the POC diagnostics questionnaire-based reporting of haematuria and dysuria, clinical examination, urinalysis by dipsticks, and urine albumin-to-creatinine ratio (UACR). Attributable fractions were used to quantify the proportion of morbidity attributable to S. haematobium infection. Based on results of attributable fractions, UACR was identified as the most reliable tool for detecting schistosome-related morbi...Continue Reading

Associated Clinical Trials

References

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May 26, 2011·PLoS Neglected Tropical Diseases·Francisca MutapiTakafira Mduluza
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Citations

Oct 17, 2017·International Journal of Environmental Research and Public Health·Erick Sierra-DiazHernandez-Flores Georgina
Sep 16, 2017·Disaster Medicine and Public Health Preparedness·Ziling NiFen Yang
May 18, 2020·BMC Infectious Diseases·Sandrine Lydie Oyegue-LiabaguiJean Bernard Lekana-Douki
Apr 9, 2017·Infectious Diseases of Poverty·Takafira Mduluza, Francisca Mutapi
Feb 9, 2018·PLoS Neglected Tropical Diseases·Derick N M OsakunorFrancisca Mutapi

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Software Mentioned

MjM
SAS
NMDS
PCORD
StatXact
CLINITEK Status + Analyzer
Cystel

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