Identifying and Quantifying Neurological Disability via Smartphone

Frontiers in Neurology
Alexandra K BoukhvalovaBibiana Bielekova

Abstract

Embedded sensors of the smartphones offer opportunities for granular, patient-autonomous measurements of neurological dysfunctions for disease identification, management, and for drug development. We hypothesized that aggregating data from two simple smartphone tests of fine finger movements with differing contribution of specific neurological domains (i.e., strength & cerebellar functions, vision, and reaction time) will allow establishment of secondary outcomes that reflect domain-specific deficit. This hypothesis was tested by assessing correlations of smartphone-derived outcomes with relevant parts of neurological examination in multiple sclerosis (MS) patients. We developed MS test suite on Android platform, consisting of several simple functional tests. This paper compares cross-sectional and longitudinal performance of Finger tapping and Balloon popping tests by 76 MS patients and 19 healthy volunteers (HV). The primary outcomes of smartphone tests, the average number of taps (per two 10-s intervals) and the average number of pops (per two 26-s intervals) differentiated MS from HV with similar power to traditional, investigator-administered test of fine finger movements, 9-hole peg test (9HPT). Additionally, the secondar...Continue Reading

References

Jun 4, 1999·Brain : a Journal of Neurology·G R CutterE Willoughby
Oct 1, 2004·Brain : a Journal of Neurology·Katrin MorgenLeonardo G Cohen
Sep 6, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laura K SheridanRobert A Zucker
Oct 31, 2015·Neurology. Neuroimmunology and Neuroinflammation·Riley BovePhilip L De Jager
Mar 5, 2016·Scientific Data·Brian M BotAndrew D Trister
Mar 24, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Diego CadavidDaniel Mikol
Mar 4, 2016·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Julia M BaltoRobert W Motl
Jul 7, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Makoto TanigawaBibiana Bielekova
Oct 24, 2018·Annals of Clinical and Translational Neurology·Peter KosaBibiana Bielekova

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Citations

May 16, 2019·QJM : Monthly Journal of the Association of Physicians·P W VinnyV Y Vishnu
Jan 22, 2020·JAMA Neurology·William O TatumUNKNOWN OSmartViE Investigators
Aug 5, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Sarah AlexanderJeremy Chataway
Jun 14, 2019·Frontiers in Neurology·Alexandra K BoukhvalovaBibiana Bielekova
Feb 26, 2020·Nature Immunology·Susan K PierceNaomi Taylor
Jan 20, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·William O TatumUNKNOWN OSmartViE Collaborators
Feb 22, 2021·Epilepsy & Behavior : E&B·Cemal KarakasZulfi Haneef
Aug 17, 2021·Journal of Physical Therapy Science·Richard W Bohannon, Inga Wang
Nov 26, 2021·International Journal of Rheumatic Diseases·Busra CandiriServet Yolbas
Jan 12, 2022·Seminars in Neurology·Anoopum S Gupta
May 27, 2020··Andreas LutterottiDavid Lindlbauer

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Clinical Trials Mentioned

NCT00794352
NCT03109288

Software Mentioned

Google Pixel XL
NeurEx
CombiWISE
Python
iOS
Android Studio
android
NeurEx app
Android Package (

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