Identifying antimicrobial multiresistance patterns of Escherichia coli sampled from diarrhoeic calves by cluster analysis techniques: a way to guide research on multiresistance mechanisms

Zoonoses and Public Health
M-A BotrelD Calavas

Abstract

Multiresistance is a critical issue. This study points out the usefulness of cluster analysis techniques to describe concisely the antimicrobial susceptibility patterns of bacterial isolates in a way that could effectively help in generating hypotheses on multiresistance mechanisms. Data were selected from the French antimicrobial resistance survey network on veterinary pathogens (Resapath). They were related to 1545 Escherichia coli isolates, which were isolated from faecal samples of diarrhoeic calves in France between 2002 and 2006. Ten clusters of isolates displaying similar features in terms of resistance profile to 13 relevant antimicrobials were computed. The presence of two to ten simultaneous resistances was detected in nine out of the ten clusters. Looking at potential mechanistic interpretations, results may suggest genetic links between some resistance mechanisms, but this should be confirmed by molecular investigation of the corresponding isolates. Looking at therapeutical potential implications, the high level of resistance and multiresistance to several antimicrobials observed in E. coli makes a critical reassessment of empiric oral antimicrobial therapy in calves highly desirable.

References

Oct 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J L MartelJ P Lafont
May 5, 2000·International Journal of Antimicrobial Agents·A CaprioliR Helmuth
Dec 15, 2000·Trends in Microbiology·H C DavisonM E Woolhouse
Jan 30, 2002·International Journal of Antimicrobial Agents·Maurice R ScavizziAlexis Elbhar
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·James PoupardChad Stewart
Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David M Livermore
Apr 3, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G CornagliaUNKNOWN ESCMID Study Group for Antimicrobial Resistance Surveillance
Nov 5, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·F M Aarestrup
Nov 20, 2004·Nature Reviews. Microbiology·Mitchell J SchwaberYehuda Carmeli
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·Heike von Baum, Reinhard Marre
Dec 7, 2005·Research in Veterinary Science·H MoyaertA Decostere
Mar 15, 2006·International Journal of Medical Microbiology : IJMM·Jürgen Wallmann
Feb 9, 2007·International Journal of Antimicrobial Agents·O Colin StineJ Glenn Morris

❮ Previous
Next ❯

Citations

Aug 22, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Kohei MakitaYutaka Tamura
Nov 3, 2011·BMC Genomics·Aline MetrisArnoud H M van Vliet
Apr 30, 2019·Research in Veterinary Science·Anne Davin-RegliJean-Marie Pagès

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.