Identifying biomarker patterns and predictors of inflammation and myocardial stress

Journal of Cardiac Failure
Ruth M Masterson CreberBarbara Riegel

Abstract

Regular exercise is recommended to improve outcomes in patients with heart failure. Exercise is known to decrease inflammation and thought to decrease myocardial stress; however, studies of exercise in heart failure have had mixed results on levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hsCRP). A multimarker analysis may help to identify distinct subgroups of patients who respond to exercise. Our primary study objective was to identify common and distinct patterns of change in hsCRP and NT-proBNP and to quantify the influence of exercise therapy on the observed patterns of change. NT-proBNP and hsCRP were assessed in a random sample of 320 participants from the biomarker substudy of HF-ACTION, a randomized clinical trial of exercise training versus usual care in patients with stable and chronic heart failure. Growth mixture modeling was used to identify unique biomarker patterns over 12 months. Three statistically independent and clinically meaningful biomarker patterns of NT-proBNP and hsCRP were identified. Two patterns were combined and compared with the "low/stable" pattern, which was characterized by the lowest levels of NT-proBNP and hsCRP over time. Participants ...Continue Reading

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Citations

May 12, 2015·Journal of Cardiac Failure·Stein Ørn, Magne Thoresen
Jun 21, 2017·European Journal of Preventive Cardiology·Wouter C Meijers, Rudolf A de Boer
Nov 23, 2019·International Journal of Behavioral Medicine·Dionne KessingNina Kupper
Oct 29, 2020·The Journal of Cardiovascular Nursing·Jessica Harman ThompsonChristopher S Lee

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