Identifying brain nociceptive information transmission in patients with chronic somatic pain

Pain Reports
Don A DavisA Vania Apkarian

Abstract

Recent advances regarding mechanisms of chronic pain emphasize the role of corticolimbic circuitry in predicting risk for chronic pain, independently from site of injury-related parameters. These results compel revisiting the role of peripheral nociceptive signaling in chronic pain. We address this issue by examining what brain circuitry transmit information regarding the intensity of chronic pain and how this information may be related to a common co-morbidity, depression. Resting state functional MRI was used in a large group of chronic pain patients (n=40 chronic back pain, CBP, and n=44 osteoarthritis, OA patients), and in comparison to healthy subjects (n=88). We used a graph theoretical measure, degree count, to investigate voxel-wise information sharing/transmission in the brain. Degree count, a functional connectivity based measure, identifies the number of voxels functionally connected to every given voxel. Subdividing the chronic pain cohort into discovery, replication, and also for overall group we show that only degree counts of diencephalic voxels centered in the ventral lateral thalamus reflected intensity of chronic pain, independently of depression. Pain intensity was reliably associated with degree count of the...Continue Reading

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Citations

Sep 13, 2019·Current Stem Cell Research & Therapy·Jinxuan RenLina Yu
Feb 20, 2021·Journal of Neuroscience Research·Jared J TannerKimberly T Sibille

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Software Mentioned

FSL
Brain Connectivity Toolbox
FMRIB

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