Identifying clinical risk factors in recurrent idiopathic deep venous thrombosis

Medicina clínica
M Lourdes Del Río SoláCarlos Vaquero Puerta

Abstract

Oral anticoagulant therapy for more than 6 months in patients with an episode of idiopathic thromboembolic disease is controversial. The objective was to determine predictive clinical signs that identify patients at increased risk of thromboembolic recurrence after stopping anticoagulant therapy for 6 months after an episode of idiopathic deep vein thrombosis (DVT). A prospective study which included 306 consecutive patients with a first episode of idiopathic DVT from June 2012 to June 2014. Predictor variables of recurrent thromboembolic disease and episodes of recurrence during follow-up of the patients (28.42 months) were collected. We performed a multivariate analysis to analyze possible predictors (P<.20) and an analysis of Kaplan-Meier to establish mean recurrence-free survival. We identified 91 episodes of residual vein thrombosis on follow-up of the patients (37.5% men and 20.3% women) (OR 1.84; 95% CI 1.25-2.71). In the Cox regression analysis stratified by gender, variables showed significant presence of hyperechoic thrombus (P=.001) in males, and persistence of residual thrombus in women (P=.046). The mean recurrence-free survival was shorter in both groups. The presence of echogenic thrombus in men and the existence...Continue Reading

References

Sep 4, 1997·The New England Journal of Medicine·UNKNOWN Columbus InvestigatorsR Baildon
Jul 2, 2003·Annals of Internal Medicine·Giancarlo AgnelliUNKNOWN Warfarin Optimal Duration Italian Trial Investigators
Oct 27, 2006·The New England Journal of Medicine·Gualtiero PalaretiUNKNOWN PROLONG Investigators

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