Identifying Common Pathogens in Periprosthetic Joint Infection and Testing Drug-resistance Rate for Different Antibiotics: A Prospective, Single Center Study in Beijing

Orthopaedic Surgery
Zhang-Lai LiJianhao Lin

Abstract

The aim of this study is to identify the common microorganisms causing PJI as well as the drug-resistant spectrum for each microorganism, to help orthopaedic surgeons to choose appropriate antibiotics. One hundred and sixty patients who suffered from failure of primary or revision total hip or knee arthroplasty for different reasons were prospectively recruited. These patients underwent revision or re-revision total hip or knee arthroplasty in our institution between August 2013 to August 2016. The details of patients' medical history and comprehensive physical examination, as well as demographic data were recorded precisely. Routine blood test results, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) levels, and synovial leukocyte counts were collected. Additionally, aspiration was conducted during surgery to avoid pollution unless when PJI was strongly suspected, in which case, joint puncture and aspiration were conducted before surgery. Intraoperatively, the implant-surrounding tissue and the prosthesis were collected under aseptic conditions. Postoperatively, the prosthesis, implant-surrounding tissue and synovium were sent to the laboratory imm...Continue Reading

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Citations

Feb 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Kai WangLingyun Lv
Feb 21, 2021·The Journal of Arthroplasty·Bernhard J H FrankJochen G Hofstaetter
Mar 16, 2021·Arthroplasty Today·Andrew McGuireSteve Mann
Mar 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dongzhu MaKenneth L Urish

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