Identifying context-specific gene profiles of social, reproductive, and mate preference behavior in a fish species with female mate choice.

Frontiers in Neuroscience
M E RamseyM E Cummings

Abstract

Sensory and social inputs interact with underlying gene suites to coordinate social behavior. Here we use a naturally complex system in sexual selection studies, the swordtail, to explore how genes associated with mate preference, receptivity, and social affiliation interact in the female brain under specific social conditions. We focused on 11 genes associated with mate preference in this species (neuroserpin, neuroligin-3, NMDA receptor, tPA, stathmin-2, β-1 adrenergic receptor) or with female sociosexual behaviors in other taxa (vasotocin, isotocin, brain aromatase, α-1 adrenergic receptor, tyrosine hydroxylase). We exposed females to four social conditions, including pairings of differing mate choice complexity (large males, large/small males, small males), and a social control (two females). Female mate preference differed significantly by context. Multiple discriminant analysis (MDA) of behaviors revealed a primary axis (explaining 50.2% between-group variance) highlighting differences between groups eliciting high preference behaviors (LL, LS) vs. other contexts, and a secondary axis capturing general measures distinguishing a non-favored group (SS) from other groups. Gene expression MDA revealed a major axis (68.4% betw...Continue Reading

Citations

Jul 24, 2013·Annual Review of Genomics and Human Genetics·David F Clayton
Jul 2, 2014·Current Opinion in Neurobiology·Chelsea A Weitekamp, Hans A Hofmann
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gina M CalabreseMolly E Cummings
Sep 19, 2016·Seminars in Cell & Developmental Biology·Tet Woo LeeNigel P Birch
Sep 1, 2017·Proceedings. Biological Sciences·Leigh W Simmons, Maxine Lovegrove
Jul 11, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Molly E Cummings
Oct 10, 2018·Nature Ecology & Evolution·Natasha I BlochJudith E Mank
Sep 9, 2020·The Journal of Experimental Biology·Ross S DeAngelis, Hans A Hofmann

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Methods Mentioned

BETA
PCR
MDA

Software Mentioned

MacVector
R
ade
MASS package
Biosystems Sequence Detection
CCA
Gene MDA
Applied
candisc

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