Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study

The British Journal of Dermatology
R B WarrenPSORT Consortium and on behalf of the BADBIR Study Group

Abstract

Biologic therapies have revolutionized the treatment of moderate-to-severe psoriasis. However, for reasons largely unknown, many patients do not respond or lose response to these drugs. To evaluate demographic, social and clinical factors that could be used to predict effectiveness and stratify response to biologic therapies in psoriasis. Using a multicentre, observational, prospective pharmacovigilance study (BADBIR), we identified biologic-naive patients starting biologics with outcome data at 6 (n = 3079) and 12 (n = 3110) months. Associations between 31 putative predictors and outcomes were investigated in univariate and multivariable regression analyses. Potential stratifiers of treatment response were investigated with statistical interactions. Eight factors associated with reduced odds of achieving ≥ 90% improvement in Psoriasis Area and Severity Index (PASI 90) at 6 months were identified (described as odds ratio and 95% confidence interval): demographic (female sex, 0·78, 0·66-0·93); social (unemployment, 0·67, 0·45-0·99); unemployment due to ill health (0·62, 0·48-0·82); ex- and current smoking (0·81, 0·66-0·99 and 0·79, 0·63-0·99, respectively); clinical factors (high weight, 0·99, 0·99-0·99); psoriasis of the palms ...Continue Reading

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Citations

May 8, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A Di CesareF Prignano
Jan 30, 2020·Clinical and Translational Science·Shan PanUNKNOWN BADBIR Study Group, the BSTOP Study Group, the PSORT Consortium
Aug 25, 2020·Archives of Toxicology·Jasna Grželj, Marija Sollner Dolenc
Jul 19, 2019·Frontiers in Immunology·Yisheng WongKenji Kabashima
Apr 2, 2020·Expert Opinion on Drug Safety·Leila AsfourRichard B Warren
Jul 10, 2019·The Journal of Dermatological Treatment·Andreas PinterMaximilian Reinhardt
Jun 12, 2020·The British Journal of Dermatology·E Veysey
Oct 31, 2020·The Journal of International Medical Research·Hang ZhouYuwen Su
Mar 28, 2021·The Journal of Investigative Dermatology·Zenas Z N YiuUNKNOWN PSORT Consortium
Apr 5, 2021·Lancet·Christopher E M GriffithsJonathan N W N Barker
Apr 9, 2021·The British Journal of Dermatology·N GeifmanUNKNOWN BADBIR Study Group, on behalf of the PSORT Consortium
May 16, 2021·The British Journal of Dermatology·G DalalUNKNOWN PSORT consortium
Jul 14, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·N WatsonS C Weatherhead
Aug 8, 2021·Nature Communications·Rosa Andres-EjarqueUNKNOWN PSORT Consortium
Jun 16, 2021·The British Journal of Dermatology·I Y K IskandarUNKNOWN on behalf the British Association of Dermatologists Biologics and Immunomodulators Register and Psoriasis Stratification to

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