Identifying distinct trajectories of change in young breast cancer survivors' sexual functioning

Psycho-oncology
Christiana von HippelAnn Partridge

Abstract

To identify and characterize distinct trajectories of change in young women's sexual functioning over the first 5 years following breast cancer diagnosis. Group-based trajectory modeling was applied to the sexual functioning of 896 women diagnosed with stage I-IV breast cancer at age 40 or younger. The Cancer Rehabilitation Evaluation System was used to evaluate women's symptoms of sexual dysfunction annually for 5 years. Five distinct trajectories of sexual functioning were identified: one asymptomatic, one minimally symptomatic, two moderately symptomatic, and one severely symptomatic trajectory. Twelve percent of women were asymptomatic throughout follow-up. The plurality of women experienced stable mild symptoms (42%). Among those with moderate symptoms, some experienced improvement over time (22%) while others experienced deterioration (13%); 11% experienced stable severe symptoms that did not remit over time. Independent predictors of experiencing a symptomatic rather than asymptomatic trajectory (P < 0.05, two-sided) included diagnosis with stage 2 versus 1 disease, ER positive disease treated with oophorectomy or ovarian suppression, being partnered, having anxiety, poorer body image, and greater musculoskeletal pain. W...Continue Reading

Associated Clinical Trials

Nov 9, 2011·Ann H. Partridge, MD, MPH

References

Jan 1, 1992·Journal of Sex & Marital Therapy·H S Kaplan
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BinesM A Cobleigh
Jan 1, 1996·Breast Cancer Research and Treatment·P A GanzL Petersen
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A GanzG E Wyatt
Feb 18, 1999·JAMA : the Journal of the American Medical Association·E O LaumannR C Rosen
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E MortimerJ H Rowland
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A GanzJ H Rowland
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R DayB Fisher
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G BerglundL E Rutquist
Feb 6, 2004·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Vicki S HelgesonHoward Seltman
Mar 5, 2004·Journal of the National Cancer Institute·Patricia A GanzThomas R Belin
Mar 17, 2004·Psycho-oncology·Joan R BloomPriscilla J Banks
May 11, 2004·Psycho-oncology·Nancy E AvisJaneen Manuel
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Candyce H KroenkeMichelle D Holmes
Mar 17, 2005·Journal of the National Cancer Institute·Annette L StantonPatricia A Ganz
Nov 16, 2005·Psycho-oncology·Pat FobairJoan R Bloom
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephanie R BurwellNancy E Avis
Nov 5, 2009·Journal of General Internal Medicine·Elyse R ParkLisa Diller
May 5, 2010·Maturitas·Emilee GilbertJ Perz
Jul 6, 2010·Journal of Cancer Survivorship : Research and Practice·Michelle E MeliskoHope S Rugo
Sep 10, 2011·Breast Cancer Research and Treatment·Sally TaylorGalina Velikova
Jan 25, 2012·Journal of the National Cancer Institute·Jessica Howard-AndersonAnnette L Stanton
Jun 21, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·H KeddeC Wijsen
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon L Bober, Veronica Sanchez Varela
Feb 15, 2013·The Journal of Sexual Medicine·Michael Krychman, Leah S Millheiser
Mar 21, 2013·The Journal of Sexual Medicine·Kathryn E FlynnKevin P Weinfurt
Jun 4, 2014·Cancer·Shoshana M RosenbergAnn H Partridge
Dec 17, 2014·The New England Journal of Medicine·Prudence A FrancisUNKNOWN International Breast Cancer Study Group
Mar 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karin RibiGini F Fleming

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gastrointestinal Oncology
Jennifer C Averyt, Patricia W Nishimoto
Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health
Christiana von HippelRulla Tamimi
© 2022 Meta ULC. All rights reserved