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Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

PLoS Computational Biology

Sep 1, 2015

Songjian LuXinghua Lu

Abstract

An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins within a common signaling pathway exhibit...read more

Mentioned in this Paper

TP53 gene
CCNE1 gene
Ovarian Diseases
Tumor Cells, Uncertain Whether Benign or Malignant
EGFR
Prostatic Neoplasms
Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Gene Expression Regulation, Neoplastic
Bladder Neoplasm
44
2
Paper Details
References
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Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

PLoS Computational Biology

Sep 1, 2015

Songjian LuXinghua Lu

PMID: 26317392

DOI: 10.1371/journal.pcbi.1004257

Abstract

An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins within a common signaling pathway exhibit...read more

Mentioned in this Paper

TP53 gene
CCNE1 gene
Ovarian Diseases
Tumor Cells, Uncertain Whether Benign or Malignant
EGFR
Prostatic Neoplasms
Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Gene Expression Regulation, Neoplastic
Bladder Neoplasm
44
2

Similar Papers Found In These Feeds

Paper Details
References
  • References49
  • Citations4
12345
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