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Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

PLoS Computational Biology

Aug 1, 2015

Songjian LuXinghua Lu

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Abstract

An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins within a common signaling pathway exhibit...read more

Mentioned in this Paper

Bladder Neoplasm
Malignant Neoplasm of Breast
Malignant Neoplasms
Cell Cycle
Colorectal Neoplasms
Estrogens
Gene Amplification
Gene Expression
Gene Expression Regulation, Neoplastic
Genes
43
2
Paper Details
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  • Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

    PLoS Computational Biology

    Aug 1, 2015

    Songjian LuXinghua Lu

    PMID: 26317392

    DOI: 10.1371/journal.pcbi.1004257

    Abstract

    An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins within a common signaling pathway exhibit...read more

    Mentioned in this Paper

    Bladder Neoplasm
    Malignant Neoplasm of Breast
    Malignant Neoplasms
    Cell Cycle
    Colorectal Neoplasms
    43
    2

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    References
    • References49
    • Citations2
    • References49
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