Identifying Dysregulated lncRNA-Associated ceRNA Network Biomarkers in CML Based on Dynamical Network Biomarkers

BioMed Research International
Junhua XuJie Gao

Abstract

The incidence of chronic myeloid leukemia (CML) is increasing year by year, which is a serious threat to human health. Early diagnosis can reduce mortality and improve prognosis. LncRNAs have been shown to be effective biomarkers for a variety of diseases and can act as competitive endogenous RNA (ceRNA). In this study, the dysregulated lncRNA-associated ceRNA networks (DLCN) of the chronic phase (CP), accelerated phase (AP), and blastic crisis (BC) for CML are constructed. Then, based on dynamic network biomarkers (DNB), some dysregulated lncRNA-associated ceRNA network biomarkers of CP, AP, and BC for CML are identified according to DNB criteria. Thus, a lncRNA (SNHG5) is identified from DLCN_CP, a lncRNA (DLEU2) is identified from DLCN_AP, and two lncRNAs (SNHG3, SNHG5) are identified from DLCN_BC. In addition, the critical index (CI) used to detect disease outbreaks shows that CML occurs in CP, which is consistent with clinical medicine. By analyzing the functions of the identified ceRNA network biomarkers, it has been found that they are effective lncRNA biomarkers directly or indirectly related to CML. The result of this study will help deepen the understanding of CML pathology from the perspective of ceRNA and help disco...Continue Reading

References

Jan 18, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Kip A WestPhillip A Dennis
Nov 26, 2003·Journal of Mammary Gland Biology and Neoplasia·Sarah HatsellPamela Cowin
Jul 25, 2012·BMC Cancer·Stephany CorrêaEliana Abdelhay
Sep 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ting ZhangLi Liu
Mar 13, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shanshan JiangLi Ye
Jun 10, 2016·Nature·Sheela A AbrahamTessa L Holyoake
Feb 2, 2018·Medical Oncology·Ana Paula Zambuzi Cardoso MarsolaFabíola Attié de Castro

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Datasets Mentioned

BETA
GSE47927

Software Mentioned

AP
CP
DLCN
SeqMap

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