Identifying interactions between genes and early environment in the mouse

Genes, Brain, and Behavior
Valeria CarolaC Gross

Abstract

Interactions between genetic and early environmental factors are recognized to play a critical role in modulating susceptibility to disease, particularly mental illness. In order to better understand such mechanisms at the molecular level, we have developed a screening paradigm in mice that allows us to test the ability of targeted mutations in candidate genes to modify susceptibility to the long-term effects of different maternal environment. Offspring of genetically identical F1 hybrid dams produced by reciprocal breeding of C57BL/6 and BALB/c parents show alterations in anxiety-related behavior as a consequence of their different maternal environment. Introduction of targeted mutations into these offspring via the father allows for the identification of candidate genes that alter these maternal effects. Our strategy offers several advantages over other methods to study maternal effects, including the use of genetically identical parents, the ability to identify both prenatal and postnatal effects, the straightforward introduction of mutations and its adaptability to high-throughput screening. In order to test the utility of this paradigm to screen candidate genes, we tested for gene-environment interactions involving loss-of...Continue Reading

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Citations

Aug 4, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Eli ReuveniCornelius Gross
Sep 11, 2009·Genes, Brain, and Behavior·C ZanettiniF R D'Amato
Feb 6, 2010·Genes, Brain, and Behavior·Valeria Carola, Cornelius Gross
Sep 7, 2012·Genes, Brain, and Behavior·M CampolongoA M Depino
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Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rahia MashoodhFrances A Champagne
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Oct 15, 2013·Autism Research : Official Journal of the International Society for Autism Research·Luciana Lucchina, Amaicha Mara Depino
Jul 27, 2011·Hormones and Behavior·Rebecca S HeimingNorbert Sachser
Aug 20, 2014·Frontiers in Behavioral Neuroscience·Valeria CarolaCornelius T Gross
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Apr 8, 2010·Disease Models & Mechanisms·Alessandro BartolomucciCornelius Gross

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