Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis

Medicine
Junjun LingWeidong Cheng

Abstract

Alzheimer disease (AD) is a progressive neurodegenerative disease, the etiology of which remains largely unknown. Accumulating evidence indicates that elevated manganese (Mn) in brain exerts toxic effects on neurons and contributes to AD development. Thus, we aimed to explore the gene and pathway variations through analysis of high through-put data in this process.To screen the differentially expressed genes (DEGs) that may play critical roles in Mn-induced AD, public microarray data regarding Mn-treated neurocytes versus controls (GSE70845), and AD versus controls (GSE48350), were downloaded and the DEGs were screened out, respectively. The intersection of the DEGs of each datasets was obtained by using Venn analysis. Then, gene ontology (GO) function analysis and KEGG pathway analysis were carried out. For screening hub genes, protein-protein interaction network was constructed. At last, DEGs were analyzed in Connectivity Map (CMAP) for identification of small molecules that overcome Mn-induced neurotoxicity or AD development.The intersection of the DEGs obtained 140 upregulated and 267 downregulated genes. The top 5 items of biological processes of GO analysis were taxis, chemotaxis, cell-cell signaling, regulation of cellul...Continue Reading

References

Oct 18, 2000·FEBS Letters·J Nunan, D H Small
Sep 27, 2006·Bioinformatics·Jeffrey T Chang, Joseph R Nevins
Feb 7, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Shahriar Gharibzadeh, Sayed Shahabuddin Hoseini
Oct 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun Kyoung LeeHwan Tae Park
Aug 4, 2011·Journal of Alzheimer's Disease : JAD·José Luis Vázquez-HigueraOnofre Combarros
Nov 30, 2012·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Mar 29, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Raúl González-DomínguezJosé Luis Gómez-Ariza
Apr 18, 2015·BioMed Research International·Jiyang YuJose M Silva
Jun 27, 2015·International Journal of Cosmetic Science·J M GillbroA Mavon
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Zi-Xuan WangJin-Tai Yu
Jan 8, 2016·Turkish Journal of Medical Sciences·Emine Rabia KoçAbdurrahman Said Bodur
Jun 16, 2016·Environmental Health : a Global Access Science Source·Jin-Young Min, Kyoung-Bok Min
Dec 21, 2016·Chemical Biology & Drug Design·Sourav KumarAmal Chandra Mondal
Jan 19, 2017·Annual Review of Medicine·W Vallen GrahamThomas P Sakmar
Mar 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Bo-Jeng WangYung-Feng Liao
Jul 26, 2017·PloS One·Kristoffer SøbergJon Kristen Laerdahl
Oct 21, 2017·Brain : a Journal of Neurology·Patricia Rodriguez-RodriguezAngel Cedazo-Minguez
Nov 21, 2017·Brain : a Journal of Neurology·Fernando J BustosBrigitte van Zundert

❮ Previous
Next ❯

Citations

Nov 7, 2019·Journal of Neurochemistry·Israel C NnahMarianne Wessling-Resnick
Aug 18, 2020·Expert Review of Neurotherapeutics·Airton C MartinsMichael Aschner
Sep 25, 2019·International Journal of Environmental Research and Public Health·Airton Cunha MartinsMichael Aschner
Feb 24, 2021·Expert Opinion on Drug Metabolism & Toxicology·Airton C MartinsMichael Aschner
May 1, 2021·International Journal of Molecular Sciences·Alexey A TinkovMichael Aschner
Jun 22, 2018·ACS Applied Materials & Interfaces·Xiaoru ShaoYunfeng Lin

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE48350
GSE70845

Methods Mentioned

BETA
Expression

Software Mentioned

CMAP
Cytoscape
Gather
STRING
cytoHubba
GEO2R

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Jun ShiBingmei Zhu
© 2022 Meta ULC. All rights reserved