Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation

American Journal of Obstetrics and Gynecology
Clare L WhiteheadStephen Tong

Abstract

Late-onset fetal growth restriction (FGR) is often undetected prior to birth, which puts the fetus at increased risk of adverse perinatal outcomes including stillbirth. Measuring RNA circulating in the maternal blood may provide a noninvasive insight into placental function. We examined whether measuring RNA in the maternal blood at 26-30 weeks' gestation can identify pregnancies at risk of late-onset FGR. We focused on RNA highly expressed in placenta, which we termed "placental-specific genes." This was a case-control study nested within a prospective cohort of 600 women recruited at 26-30 weeks' gestation. The circulating placental transcriptome in maternal blood was compared between women with late-onset FGR (<5th centile at >36+6 weeks) and gestation-matched well-grown controls (20-95th centile) using microarray (n = 12). TaqMan low-density arrays, reverse transcription-polymerase chain reaction (PCR), and digital PCR were used to validate the microarray findings (FGR n = 40, controls n = 80). Forty women developed late-onset FGR (birthweight 2574 ± 338 g, 2nd centile) and were matched to 80 well-grown controls (birthweight 3415 ± 339 g, 53rd centile, P < .05). Operative delivery and neonatal admission were higher in the F...Continue Reading

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Citations

Mar 7, 2017·American Journal of Obstetrics and Gynecology·Roberto RomeroAdi L Tarca
Jun 9, 2017·Human Molecular Genetics·Irina ManokhinaWendy P Robinson
May 10, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Li TangWenming Xu
Jun 27, 2020·Zeitschrift für Geburtshilfe und Neonatologie·Demet Aydogan KırmızıEthem Serdar Yalvac

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